100442-33-9

Basic information

• Product Name: 2,N-Dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol
• Synonyms: 2,N-DIMETHYL-N-(3,3-DIPHENYLPROPYL)-1-AMINO-2-PROPANOL;1-(3,3-DIPHENYL-N-METHYLPROPYLAMINO)-2-METHYL-2-PROPANOL;1-[(3,3-Diphenylpropyl)methylamino]-2-methyl-2-propanol ;2,N-Dimethyl-N-(3,3-Diphenylpr;1-(3,3-diphenyl-N-methylpropylamino)-2-methyl-2-propanol (intermediate of lercanidipine);2,N-dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol (intermediate of lercanidipine);2,N-DIMEHYL-n(3,3-DIPHENYLPROPYL)-1-amino-2-propanol;LERCANIDIPINEBRANCH
• CAS NO: 100442-33-9
• Molecular Formula: C₂₀H₂₇NO
• Molecular Weight: 297.43
• EINECS: 239-349-0
• Product Categories: Chemical intermediate for Lercanidipine;Amines;(intermediate of lercanidipine);Chemical Amines;Intermediates & Fine Chemicals;Pharmaceuticals;Lercanidipine Hydrochloride;Lercanidipine intermediate
• Mol File: 100442-33-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 145°C/0.2mmHg(lit.)
• Flash Point: 164.7 °C
• Appearance: slightly brown liquid
• Density: 1.025 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.5430 to 1.5470
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 14.90±0.29(Predicted)
• Stability: Normal temperature and pressure
• CAS DataBase Reference: 2,N-Dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,N-Dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol(100442-33-9)
• EPA Substance Registry System: 2,N-Dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol(100442-33-9)

Safety Data

• Hazardous Substances Data: 100442-33-9(Hazardous Substances Data)

Usage

Chemical Properties

Slightly Brown Liquid

Uses

Different sources of media describe the Uses of 100442-33-9 differently. You can refer to the following data:
1. Lercanidipine Intermediate
2. Lercanidipine Intermediate.

InChI:InChI=1/C20H27NO/c1-20(2,22)16-21(3)15-14-19(17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-13,19,22H,14-16H2,1-3H3

Upstream product

• 558-42-9 3-chloro-2-methylpropan-2-ol 
• 28075-29-8 N-methyl-3,3-diphenylpropylamine 

Downstream Products

• 100427-51-8 1,1,N-trimethyl-N-(3,3-diphenylpropy)-2-aminoethyl acetoacetate 
• 132866-11-6 lercanidipine hydrochloride 
• 786625-22-7 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-{2-[(3,3-diphenyl-propyl)-methyl-amino]-1,1-dimethyl-ethyl} ester 5-ethyl ester 
• 210579-45-6 2-[1-(3-Nitro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid 2-[(3,3-diphenyl-propyl)-methyl-amino]-1,1-dimethyl-ethyl ester 
• 100427-26-7 lercanidipine 

Relevant articles and documents

Asymmetric N-(3,3-diphenylpropyl)aminoalkyl esters of 4-aryl-2,6- dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acids with antihypertensive activity

A series of asymmetric 4-aryl-1,4-dihydropyridine-3,5-dicarboxylates characterized by the presence of a 3,3-diphenylpropylamino moiety in one of the ester groups were synthesized. They exhibited remarkable antihypertensive activity in spontaneously hypertensive rats as well as affinity for the 1,4- dihydropyridines binding site labelled by 3H-nitrendipine in the calcium channel. Introduction of this bulky and lipophilic amine confers to the whole series an elevated level of antihypertensive activity and a long duration of action, a structure-dependent modulation of the activity being found only in the subset characterized by the presence of a branched propylene bridge between the ester and the amino groups. The presence of the amino group is essential for oral activity. Out of this series, compound 9u (Rec 15/2375- lercanidipine) was selected for clinical development and obtained marketing authorization as an antihypertensive in several countries.