100448-10-0

Usage

Chemical class

Benzofuroazocine alkaloids

Natural sources

Found in certain plants and fungi

Pharmaceutical properties

Potential effects on the central nervous system

Analgesic properties

Studies suggest that the compound may have pain-relieving effects

Neuroprotective properties

The compound may have the ability to protect nerve cells from damage

Medical applications

Potential treatment for various medical conditions

Further research

The compound is of interest for additional research and potential medical applications
It's important to note that while 1,3,4,5,6,11a-hexahydro-2-methyl-2H-3,6a-methanobenzofuro(2,3-c)azocin-10-ol has shown potential in studies, more research is needed to fully understand its properties and potential applications. Additionally, the safety and efficacy of 1,3,4,5,6,11a-hexahydro-2-methyl-2H-3,6a-methanobenzofuro(2,3-c)azocin-10-ol for medical use have not been established.

InChI:InChI=1/C15H19NO2/c1-16-9-13-15(7-3-4-10(16)8-15)11-5-2-6-12(17)14(11)18-13/h2,5-6,10,13,17H,3-4,7-9H2,1H3

Upstream product

• 50-00-0 formaldehyd 
• 91-16-7 1,2-dimethoxybenzene 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 1308331-18-1 (R*)-4-allyl-1-benzyl-4-(2,3-dimethoxyphenyl)-1,2,3,4-tetrahydropyridine 
• 1308331-15-8 1-benzyl-4-(2,3-dimethoxyphenyl)-1,2,3,6-tetrahydropyridine 
• 1308331-14-7 1-benzyl-4-(2,3-dimethoxyphenyl)piperidin-4-ol 
• 100448-07-5 (+/-)-2-methyl-4-bromo-5-(2,3-dimethoxyphenyl)-2-azabicyclo<3.3.1>nonane hydrobromide 
• 100448-08-6 (+/-)-2-methyl-4-bromo-5-(2,3-dihydroxyphenyl)-2-azabicyclo<3.3.1>nonane hydrobromide 

Relevant academic research and scientific papers

Probes for narcotic receptor mediated phenomena. Part 42: Synthesis and in vitro pharmacological characterization of the N-methyl and N-phenethyl analogues of the racemic ortho-c and para-c oxide-bridged phenylmorphans

A new synthesis of N-methyl and N-phenethyl substituted ortho-c and para-c oxide-bridged phenylmorphans, using N-benzyl- rather than N-methyl-substituted intermediates, was used and the pharmacological properties of these compounds were determined. The N-

Probes for narcotic receptor mediated phenomena. 37.1 Synthesis and opioid binding affinity of the final pair of oxide-bridged phenylmorphans, the ortho- and para-b-isomers and their N-phenethyl analogues, and the synthesis of the N-phenethyl analogues of the ortho- and para-d-isomers

In the isomeric series of 12 racemic topologically rigid N-methyl analogues of oxide-bridged phenylmorphans, all but two of the racemates, the ortho- and para-b-oxide-bridged phenylmorphans 20 and 12, have remained to be synthesized. The b-isomers were very difficult to synthesize because of the highly strained 5,6-transfused ring junction that had to be formed. Our successful strategy required functionalization of the position para (or ortho) to a fluorine atom on the aromatic ring using an electron-withdrawing nitro group to activate that fluorine. The racemic N-phenethyl analogues 24 and 16 were moderately potent κ-receptor antagonists in the [35S]GTPγS assay. We synthesized the N-phenethyl-substituted oxide-bridged phenylmorphans in the ortho- and para-d-oxide-bridged phenylmorphan series (51 and 52) which had not been previously evaluated using contemporary receptor binding assays to see whether they also have higher affinity for opioid receptors than their N-methyl relatives 46 and 47.

Probes for Narcotic Receptor Mediated Phenomena. 9. Synthesis of (+/-)-(3α,6aα,11aβ)-1,3,4,5,6,11a-Hexahydro-2-methyl-2H-3,6a-methanobenzofuroazocin-10-ol, an Oxide-Bridged 5-(m-Hydroxyphenyl)morphan

The synthesis of racemic (3α,6aα,11aβ)-1,3,4,5,6,11a-hexahydro-2-methyl-2H-3,6a-methanobenzofuroazocin-10-ol (2d) is described.The route used acid-catalyzed ring closure of enamine 5 to yield the unsaturated phenylmorphan 6.Conversion of 6 to oxide