1004517-93-4Relevant academic research and scientific papers
Alternative and complementary approaches to the asymmetric synthesis of C3 substituted NH free or N-substituted isoindolin-1-ones
Lamblin, Marc,Couture, Axel,Deniau, Eric,Grandclaudon, Pierre
, p. 111 - 123 (2008/09/17)
Complementary synthetic approaches to enantiomerically pure C3 alkylated or arylated NH free or N-substituted isoindolinones have been developed. The key step is elaboration of diversely substituted 2-alkyl- and arylbenzylamines, which can be submitted to a bis-metallation process followed by interception with a carbonylating agent. They can be also converted into N-alkylbromobenzylcarbamates or into bromobenzyldicarbamates and the assembly of the titled compounds can be readily ensured by reliance upon the Parham cyclization process.
Indium - Copper-mediated barbier - Grignard-type alkylation reaction of imines in aqueous media
Shen, Zhi-Liang,Loh, Teck-Peng
, p. 5413 - 5416 (2008/09/17)
An efficient system of In/Cul/InCl3 was developed for Barbier-Grignard-type alkylation reactions of simple imines, using a one-pot condensation of various aldehydes, amines (including aliphatic and chiral version), and alkyl iodides in water or
