1004551-40-9 Usage
Uses
Used in Pharmaceutical Industry:
C31H27N3O4 is used as a sedative and antiemetic drug for its calming and nausea-reducing properties.
Used in Oncology:
C31H27N3O4 is used as an anticancer agent for its potential in treating certain types of cancer, despite its strict regulations and monitoring due to its teratogenic effects.
Used in Autoimmune Disease Treatment:
C31H27N3O4 is used as a therapeutic agent for autoimmune diseases, leveraging its interaction with biological systems to modulate immune responses.
Despite its infamous teratogenic effects when taken during pregnancy, leading to severe birth defects, thalidomide's complex chemical structure allows for its use in specific medical settings under stringent regulations and monitoring.
Check Digit Verification of cas no
The CAS Registry Mumber 1004551-40-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,4,5,5 and 1 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1004551-40:
(9*1)+(8*0)+(7*0)+(6*4)+(5*5)+(4*5)+(3*1)+(2*4)+(1*0)=89
89 % 10 = 9
So 1004551-40-9 is a valid CAS Registry Number.
1004551-40-9Relevant academic research and scientific papers
Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor
Priestley, E. Scott,De Lucca, Indawati,Zhou, Jinglan,Zhou, Jiacheng,Saiah, Eddine,Stanton, Robert,Robinson, Leslie,Luettgen, Joseph M.,Wei, Anzhi,Wen, Xiao,Knabb, Robert M.,Wong, Pancras C.,Wexler, Ruth R.
, p. 2432 - 2435 (2013/05/09)
A 6-amidinotetrahydroquinoline screening hit was driven to a structurally novel, potent, and selective FVIIa inhibitor through a combination of library synthesis and rational design. An efficient gram-scale synthesis of the active enantiomer BMS-593214 was developed, which required significant optimization of the key Povarov annulation. Importantly, BMS-593214 showed antithrombotic efficacy in a rabbit arterial thrombosis model. A crystal structure of BMS-593214 bound to FVIIa highlights key contacts with Asp 189, Lys 192, and the S2 pocket.
