100461-60-7

Basic information

• Product Name: 2-(2'-nitrophenylsulphone)indene
• Synonyms: 2-(2'-nitrophenylsulphone)indene
• CAS NO: 100461-60-7
• Molecular Weight: 301.323
• Mol File: 100461-60-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2'-nitrophenylsulphone)indene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2'-nitrophenylsulphone)indene(100461-60-7)
• EPA Substance Registry System: 2-(2'-nitrophenylsulphone)indene(100461-60-7)

Safety Data

• Hazardous Substances Data: 100461-60-7(Hazardous Substances Data)

Upstream product

• 95-13-6 1-indene 
• 7669-54-7 2-nitrobenzenesulfenyl chloride 

Downstream Products

• 100461-61-8 2-(2'-aminophenylsulphone)indene 

Relevant articles and documents

SYNTHESIS AND REACTIONS OF TRANS-2-(2'-NITROPHENYLTHIO)-1-CHLOROINDANE

The title compound was prepared by addition of 2-nitrobenzenesulphenyl chloride to indene, and proton nmr was used to prove its trans-structure.The chloro-substituent could be replaced by ethanol under very mild conditions with retention of configuration owing to anchimeric assistance by the bridging S-atom.Analogous reactions were observed with water and other alcohols (MeOH, Me2CHOH, Me3COH, PhSH).Basic nucleophiles caused dehydro-chlorination to the corresponding indenes.Reduction of the nitro-group resulted in intramolecular cyclisation to give a dihydrobenzindenothiazine 9.Thermolysis of the 2-(2'-nitrophenylthio)-1-azidoindane occurred with ring expansion to give 3-(2'-nitrophenylthio)quinoline.Oxidation of the title compound with m-chloroperoxybenzoic acid produced the corresponding sulphone which smoothly underwent reductive cyclisation to a benzindenothiazinesulphone 20.