1004619-84-4Relevant academic research and scientific papers
Chlorination/cyclodehydration of amino alcohols with SOCl2: An old reaction revisited
Xu, Feng,Simmons, Bryon,Reamer, Robert A.,Corley, Edward,Murry, Jerry,Tschaen, David
, p. 312 - 315 (2008/09/17)
(Chemical Equation Presented) A simple, one-pot preparation of cyclic amines via efficient chlorination of amino alcohols with use of SOCl2 has been developed. This approach obviates the need for the classical N-protection/O-activation/cyclization/deprotection sequence commonly employed for this type of transformation. The reaction pathways and the general scope of this method have also been investigated.
