100466-37-3

Basic information

• Product Name: Benzonitrile, 4-(bromomethyl)-2-nitro-
• CAS NO: 100466-37-3
• Molecular Formula: C8H5BrN2O2
• Molecular Weight: 241.044
• Mol File: 100466-37-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-(bromomethyl)-2-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-(bromomethyl)-2-nitro-(100466-37-3)
• EPA Substance Registry System: Benzonitrile, 4-(bromomethyl)-2-nitro-(100466-37-3)

Safety Data

• Hazardous Substances Data: 100466-37-3(Hazardous Substances Data)

Upstream product

• 26830-95-5 4-methyl-2-nitrobenzonitrile 
• 5326-34-1 4-Bromo-3-nitrotoluene 
• 89-60-1 1-chloro-4-methyl-2-nitro-benzene 

Downstream Products

• 630410-23-0 4-(morpholin-4-ylmethyl)-2-nitrobenzene carbonitrile 
• 1333470-04-4 4-(azidomethyl)-2-nitrobenzonitrile 
• 630411-49-3 4-{[(2R)-2-(methoxymethyl)pyrrolidinyl]-methyl}-2-nitrobenzenecarbonitrile 
• 630411-43-7 (4-{[(2S)-2-(methoxymethyl)pyrrolidinyl]-methyl}-2-nitrophenyl)methylamine 
• 89939-36-6 4-(hydroxymethyl)-2-nitrobenzonitrile 

Relevant articles and documents

Electrostatic fields near the active site of human aldose reductase: 2. New inhibitors and complications caused by hydrogen bonds

Vibrational Stark effect spectroscopy was used to measure electrostatic fields in the hydrophobic region of the active site of human aldose reductase (hALR2). A new nitrile-containing inhibitor was designed and synthesized, and the X-ray structure of its complex, along with cofactor NADP+, with wild-type hALR2 was determined at 1.3 A resolution. The nitrile is found to be in the proximity of T113, consistent with a hydrogen bond interaction. Two vibrational absorption peaks were observed at room temperature in the nitrile region when the inhibitor binds to wild-type hALR2, indicating that the nitrile probe experiences two different microenvironments, and these could be empirically separated into a hydrogen-bonded and non-hydrogen-bonded population by comparison with the T113A mutant, in which a hydrogen bond to the nitrile is not present. Classical molecular dynamics simulations based on the structure predict a double-peak distribution in protein electric fields projected along the nitrile probe. The interpretation of these two peaks as a hydrogen bond formation-dissociation process between the probe nitrile group and a nearby amino acid side chain is used to explain the observation of two IR bands, and the simulations were used to investigate the molecular details of this conformational change. Hydrogen bonding complicates the simplest analysis of vibrational frequency shifts as being due solely to electrostatic interactions through the vibrational Stark effect, and the consequences of this complication are discussed.

Acylated benzylmaltosides as inhibitors of smooth muscle cell proliferation

This invention provides smooth muscle cell proliferation inhibitors of formula I having the structure wherein R1, R2, R3, R4, and R5 are each, independently, hydrogen, acyl of 2-7 carbon atoms, haloac

Acetal benzylmaltosides as inhibitors of smooth muscle cell proliferation

This invention provides smooth muscle cell proliferation inhibitors of formula I having the structure with the variables defined herein.