1004760-73-9Relevant academic research and scientific papers
Structure-activity studies on seco-pancratistatin analogs: Potent inhibitors of human cytochrome P450 3A4
McNulty, James,Nair, Jerald J.,Singh, Mohini,Crankshaw, Denis J.,Holloway, Alison C.
scheme or table, p. 5607 - 5612 (2010/04/30)
Two total syntheses of fully functionalized seco-analogs of the anticancer compound pancratistatin are reported. Structure-activity relationship (SAR) studies identified potent and selective inhibitors of human cytochrome P450 3A4 (CYP3A4) and revealed se
Synthesis and biological evaluation of fully functionalized seco-pancratistatin analogues
McNulty, James,Nair, Jerald J.,Griffin, Carly,Pandey, Siyaram
experimental part, p. 357 - 363 (2009/04/11)
The total synthesis of fully functionalized polyhydroxyamide B,C-seco-analogues of the anticancer compound pancratistatin (PST) (1) is reported. Key steps include an Evans' MgCl2-promoted anti-aldol reaction between a functionalized L-threose d
Unusual magnesium chloride catalyzed non-evans anti-aldol reactions of an enolizable L-threose derivative
McNulty, James,Nair, Jerald J.,Sliwinski, Marcin,Harrington, Laura E.,Pandey, Siyaram
, p. 5669 - 5673 (2008/09/17)
The magnesium chloride catalyzed anti-aldol reaction of phenyl acetate derived oxazolidinones proceeds readily with enolizable L-threose derivative 8 to provide anti-aldol adducts in high yields and with very high diastereoselectivities. The reaction is a
