1004791-82-5Relevant academic research and scientific papers
Dynamic kinetic resolution of hemiaminals using a novel DMAP catalyst
Yamada, Shinji,Yamashita, Kaori
, p. 32 - 35 (2008)
We describe the first catalytic dynamic kinetic resolution of hemiaminals mediated by an organocatalyst. A 0.1-1 mol % catalyst loading is effective for the dynamic kinetic resolution of hemiaminals to produce esters up to 88% ee in high yields. A 10 mol % catalyst loading resulted in a decreased selectivity, whereas the selectivity increased at 50 °C. The absolute configuration is assigned on the basis of the empirical Cotton effect rule.
