1004794-77-7Relevant academic research and scientific papers
Effect of achiral and mixed chiral ligands on the asymmetric synthesis of γ-nitrophosphonates via Michael addition
Rai, Vishal,Namboothiri, Irishi N.N.
, p. 767 - 772 (2008/09/20)
Changes in the diastereo- and/or enantioselectivity were observed when the Li-cinchonine catalyzed conjugate addition of phosphonates to nitroalkenes was carried out in the presence of achiral/chiral additives. Although the conjugate addition in the absence of such additives proceeded in better yields and selectivities as reported previously, the dramatic change in selectivity in the presence of additives provides an opportunity to synthesize different stereoisomers of the product, γ-nitrophosphonate, using primarily the same chiral source.
Cinchonine catalyzed diastereo- and enantioselective Michael addition of α-lithiated phosphonates to nitroalkenes
Rai, Vishal,Mobin, Shaikh M.,Namboothiri, Irishi N.N.
, p. 2719 - 2726 (2008/09/17)
Conjugate addition of α-lithiated benzyl- and alkylphosphonates to a variety of aromatic and heteroaromatic nitroalkenes in the presence of 50 mol % of cinchonine-Li catalyst system proceeded in high yields, diastereo- and enantioselectivities in most cases.
