100480-81-7Relevant academic research and scientific papers
Studies on Hindered Phenols and Analogues. 2. 1,3-Benzoxathioles Having SRS-A Inhibiting Activity
Aizawa, Yuichi,Kanai, Tsutomu,Hasegawa, Kazuo,Yamaguchi, Takeshi,Iizuka, Yoshio,et al.
, p. 1491 - 1496 (2007/10/02)
A series of hindered phenolic 1,3-benzoxathioles (7a-1) were prepared and investigated for biological properties.Many compounds had LPO-lowering, antisuperoxide inhibiting, SRS-A inhibiting, and 5-lipoxygenase inhibiting activities.Among them, 5-hydroxy-4
1,3-benzoxathiole derivatives
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, (2008/06/13)
Compounds formula (I): STR1 in which: R1 represents a hydrogen atom, an alkyl group, a substituted alkyl group, a C2 -C6 alkenyl group, an aryl group, a substituted aryl group or an alkoxycarbonyl group wherein the alkoxy part has from 1 to 6 carbon atoms; R2 represents a hydrogen atom, a C1 -C6 alkyl group or a C3 or C4 alkenyl group; R3 represents a hydrogen atom or a C1 -C6 alkyl group; R4 represents a hydroxy group, a C1 -C21 aliphatic acyloxy group or a carbocyclic aryl carboxylic acyloxy group; R5 represents a C1 -C12 alkyl group, a C1 -C6 alkoxy group, a hydroxy group, a C1 -C7 aliphatic acyloxy group or a carbocyclic aryl carboxylic acyloxy group; R6 represents a hydrogen atom, a C1 -C6 alkyl group or a C1 -C6 alkoxy group; and n is 0, 1, or 2; and pharmaceutically acceptable salts thereof are valuable in the treatment of circulatory disorders and allergies.
