1004980-56-6 Usage
Description
(S)-α-amino-α-o-tolylacetic acid hydrochloride is a chemical compound that serves as an intermediate in the pharmaceutical industry. It is a derivative of the amino acid phenylalanine and is a chiral compound, possessing a non-superimposable mirror image. This hydrochloride salt form is water-soluble, enhancing its suitability for pharmaceutical formulations. It has been studied for its potential neuroprotective properties and evaluated in preclinical studies as a potential treatment for neurological conditions, making it a significant contributor to medicinal chemistry and drug development.
Uses
Used in Pharmaceutical Industry:
(S)-α-amino-α-o-tolylacetic acid hydrochloride is used as an intermediate for the synthesis of various pharmaceutical drugs, particularly those with potential applications in the treatment of central nervous system disorders. Its role in drug development is crucial, as it aids in the creation of medications that target neurological conditions.
Used in Neurological Treatments:
(S)-α-amino-α-o-tolylacetic acid hydrochloride is used as a potential treatment for neurological conditions due to its studied neuroprotective properties. (S)-α-amino-α-o-tolylacetic acid hydrochloride has been evaluated in preclinical studies, showcasing its potential to contribute to the development of therapies for central nervous system disorders.
Used in Drug Formulations:
The hydrochloride salt form of (S)-α-amino-α-o-tolylacetic acid is used to improve the water solubility of the compound, making it more suitable for incorporation into various pharmaceutical formulations. This enhances the compound's bioavailability and effectiveness in treating the targeted conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1004980-56-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,4,9,8 and 0 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1004980-56:
(9*1)+(8*0)+(7*0)+(6*4)+(5*9)+(4*8)+(3*0)+(2*5)+(1*6)=126
126 % 10 = 6
So 1004980-56-6 is a valid CAS Registry Number.
1004980-56-6Relevant articles and documents
Asymmetric strecker synthesis of α-arylglycines
Perez-Fuertes, Yolanda,Taylor, James E.,Tickell, David A.,Mahon, Mary F.,Bull, Steven D.,James, Tony D.
, p. 6038 - 6047 (2011/10/08)
A practically simple three-component Strecker reaction for the asymmetric synthesis of enantiopure α-arylglycines has been developed. Addition of a range of aryl-aldehydes to a solution of sodium cyanide and (S)-1-(4- methoxyphenyl)ethylamine affords highly crystalline (S,S)-α-aminonitriles that are easily obtained in diastereomerically pure form. Heating the resultant (S,S)-α-aminonitriles in 6 M aqueous HCl at reflux resulted in cleavage of their chiral auxiliary fragments and concomitant hydrolysis of their nitrile groups to afford enantiopure (S)-α-arylglycines. The enantiopurities of these (S)-α-arylglycines were determined via derivatization of their corresponding methyl esters with 2-formylphenylboronic acid and (S)-BINOL, followed by 1H NMR spectroscopic analysis of the resultant mixtures of diastereomeric iminoboronate esters.
Asymmetric Sommelet-Hauser rearrangement of N-benzylic ammonium salts
Tayama, Eiji,Kimura, Hiroshi
, p. 8869 - 8871 (2008/09/19)
(Chemical Equation Presented) [2,3] over [1,2]: The asymmetric Sommelet-Hauser rearrangement of an ammonium salt derived from N-benzylic proline-derived or N-benzylic glycine (-)-8-phenylmenthol ester is shown to proceed with remarkably high levels of stereoselectivity. The method provides unique and efficient access to optically active α-aryl amino acid derivatives.
