1004985-49-2Relevant academic research and scientific papers
Total synthesis of (-)-dolastatrienol
Leung, Lai To,Chiu, Pauline
supporting information, p. 1042 - 1049 (2015/03/31)
The first asymmetric total synthesis of the tricyclic diterpenoid natural product (-)-dolastatrienol has been accomplished using a rhodium(II)-catalyzed carbene cyclization cycloaddition cascade reaction as the key step to construct the [5.4.0]carbobicyclic core. An intramolecular Heck reaction furnished the tricyclic skeleton and a challenging methylenation completed the synthesis of the target.
Asymmetric total synthesis of (-)-indicol by a carbene cyclization- cycloaddition cascade strategy
Lam, Sze Kui,Chiu, Pauline
, p. 9589 - 9599 (2008/09/21)
The first total synthesis of a secodolastane, (-)-indicol, has been accomplished. The key reaction is a rhodium(II)-mediated carbene cyclization-cycloaddition cascade, by which the core bicyclo[5.4.0]undecane skeleton was assembled. In this one-pot reaction, a domino series of transformations resulting in the construction of three o bonds and three stereocenters was realized in good yield.
