1004985-67-4Relevant academic research and scientific papers
Asymmetric total synthesis of (-)-indicol by a carbene cyclization- cycloaddition cascade strategy
Lam, Sze Kui,Chiu, Pauline
, p. 9589 - 9599 (2008/09/21)
The first total synthesis of a secodolastane, (-)-indicol, has been accomplished. The key reaction is a rhodium(II)-mediated carbene cyclization-cycloaddition cascade, by which the core bicyclo[5.4.0]undecane skeleton was assembled. In this one-pot reaction, a domino series of transformations resulting in the construction of three o bonds and three stereocenters was realized in good yield.
