1005002-46-9Relevant academic research and scientific papers
Ni-catalyzed cascade formation of C(sp3)-C(sp3) bonds by cyclization and cross-coupling reactions of iodoalkanes with alkyl zinc halides
Phapale, Vilas B.,Bunuel, Elena,Garcia-Iglesias, Miguel,Cardenas, Diego J.
, p. 8790 - 8795 (2007)
(Chemical Equation Presented) Two for the price of one: The formation of two C(sp3)-C(sp3) bonds can be achieved in a single operation by sequential cyclization and cross-coupling of alkyl zinc bromides with iodoalkanes containing an alkene group (see scheme). The reaction is catalyzed by [Ni(Py)4CI2] in the presence of tridentate nitrogen ligands, shows a high functional-group compatibility, and seems to follow a radical mechanism.
