100501-57-3

Basic information

• Product Name: 2-METHYL-2,4,6,7-TETRAHYDRO-5H-PYRAZOLO[4,3-C]PYRIDINE-5-CARBOXYLIC ACID, TERT-BUTYL ESTER
• Synonyms: 2-METHYL-2,4,6,7-TETRAHYDRO-5H-PYRAZOLO[4,3-C]PYRIDINE-5-CARBOXYLIC ACID, TERT-BUTYL ESTER;5-Boc-2-Methyl-6,7-dihydro-2H-pyrazolo[4,3-c]pyridine;tert-Butyl 2-Methyl-6,7-dihydro-2H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate;tert-butyl 6,7-dihydro-2-methyl-2H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate
• CAS NO: 100501-57-3
• Molecular Formula: C12H19N3O2
• Molecular Weight: 237.3
• Mol File: 100501-57-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 360.1 °C at 760 mmHg
• Flash Point: 171.6 °C
• Appearance: /
• Density: 1.18 g/cm³
• Refractive Index: 1.568
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-METHYL-2,4,6,7-TETRAHYDRO-5H-PYRAZOLO[4,3-C]PYRIDINE-5-CARBOXYLIC ACID, TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-2,4,6,7-TETRAHYDRO-5H-PYRAZOLO[4,3-C]PYRIDINE-5-CARBOXYLIC ACID, TERT-BUTYL ESTER(100501-57-3)
• EPA Substance Registry System: 2-METHYL-2,4,6,7-TETRAHYDRO-5H-PYRAZOLO[4,3-C]PYRIDINE-5-CARBOXYLIC ACID, TERT-BUTYL ESTER(100501-57-3)

Safety Data

• Hazardous Substances Data: 100501-57-3(Hazardous Substances Data)

Usage

General Description

2-Methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylic acid, tert-butyl ester is a chemical compound that is commonly used in pharmaceutical research and drug development. It belongs to the pyrazolopyridine class of compounds and is often used as a building block for the synthesis of various bioactive molecules. The tert-butyl ester group attached to the carboxylic acid moiety imparts stability and lipophilicity to the compound, making it a valuable precursor for the design and synthesis of potential drug candidates. 2-METHYL-2,4,6,7-TETRAHYDRO-5H-PYRAZOLO[4,3-C]PYRIDINE-5-CARBOXYLIC ACID, TERT-BUTYL ESTER has shown promise in the development of novel drugs with potential therapeutic applications, particularly in the treatment of neurological disorders, cancer, and infectious diseases.

InChI:InChI=1/C12H19N3O2/c1-12(2,3)17-11(16)15-6-5-10-9(8-15)7-14(4)13-10/h7H,5-6,8H2,1-4H3

Upstream product

• 1430218-14-6 tert-butyl 4-(2-methylhydrazono)piperidine-1-carboxylate 
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• 230301-11-8 1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester 
• 74-88-4 methyl iodide 
• 1310796-19-0 (Z)-3-((dimethylamino)methylene)-4-oxopiperidine-1-carboxylic acid tert-butyl ester 
• 1202645-17-7 3-dimethylaminomethylene-4-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 60-34-4 methylhydrazine 

Relevant articles and documents

BICYCLIC BIS-HETEROARYL DERIVATIVES AS MODULATORS OF PROTEIN AGGREGATION

The present invention relates to certain bicyclic bis-heteroaryl compounds of Formula (I), pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and

PRMT5 INHIBITORS AND USES THEREOF

Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof:wherein Y1 is of formula (?) or formula (y):Ring Y is a 5- to 6-membered heteroaryl ring; and V4, V5, Rx, x, y, and n are as defined herein. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.

N-Alkylhydrazones of aliphatic ketones in the synthesis of 1,3,4-trisubstituted non-symmetric pyrazoles

Reactions of N-alkylhydrazones of aliphatic ketones with the Vilsmeier-Haack reagent (DMF-POCl3) were evaluated as a promising approach toward the synthesis of trisubstituted non-symmetric pyrazoles. It was found that either 1,3,4-trialkylpyrazoles or 1,3-dialkylpyrazole-4-carbaldehydes could be obtained in these transformations in high yields (72-83%), in a regioselective manner.