1005031-47-9Relevant academic research and scientific papers
A chemoselective aniline-chloropyrimidine coupling in a competing electrophilic environment
Choudhury, Anusuya,Chen, Hongfeng,Nilsen, Christopher N.,Sorgi, Kirk L.
, p. 102 - 105 (2008/09/18)
A highly chemoselective substitution on 4-amino-6-chloropyrimidine ring system having a competing aldehyde functionality has been realized with anilines which produces 4, 6-diaminopyrimidine-5-carbaldehyde in high yield. The reaction may involve the inter
A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine having dual EGFR/HER2 kinase activity: Design, synthesis, and biological activity
Hughes, Terry V.,Xu, Guozhang,Wetter, Steven K.,Connolly, Peter J.,Emanuel, Stuart L.,Karnachi, Prabha,Pollack, Scott R.,Pandey, Niranjan,Adams, Mary,Moreno-Mazza, Sandra,Middleton, Steven A.,Greenberger, Lee M.
scheme or table, p. 4896 - 4899 (2009/05/07)
A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine was synthesized and found to have potent dual EGFR/HER2 kinase inhibitory activity. The structure-based drug design of this molecule as well as the kinase and cellular inhibition of HER2 kinase dependent cell lines will be discussed.
