1005036-73-6

Basic information

• Product Name: (3aR,9bS)-6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
• Synonyms: (3aR,9bS)-6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline;CID 25113626;GCA
• CAS NO: 1005036-73-6
• Molecular Formula: C17H14F2N2
• Molecular Weight: 284.3032664
• Mol File: 1005036-73-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: room temp
• Solubility: DMSO: >10mg/mL
• CAS DataBase Reference: (3aR,9bS)-6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: (3aR,9bS)-6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline(1005036-73-6)
• EPA Substance Registry System: (3aR,9bS)-6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline(1005036-73-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1005036-73-6(Hazardous Substances Data)

Usage

Uses

Golgicide A has been used as an inhibitor in retrotransposition assays and as an inhibitor of Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 protein (GBF1) in HeLa cells.

Biochem/physiol Actions

Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1. Arf proteins are members of the Ras superfamily of small guanosine triphosphatases (GTPases) that mediate vesicular transport. Golgicide A binds within an interfacial cleft formed between Arf1 and the GBF1 Sec7 domain. Golgicide A is a unique and powerful tool for further elucidating the mechanisms underlying assembly and transport within the Golgi, comparable to the use of dynasore for studying the dynamics of dynamin-mediated clathrin coat formation.