100510-65-4

Basic information

• Product Name: 6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLE
• Synonyms: 6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLE;6-Amino-3,3-dimethylindolin-2-one;6-Amino-1,2-dihydro-3,3-dimethyl-2-oxo-3H-indole;6-Amino-3,3-dimethyl-1H-indolin-2-one
• CAS NO: 100510-65-4
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.22
• Mol File: 100510-65-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 366.6 °C at 760 mmHg
• Flash Point: 175.5 °C
• Appearance: /
• Density: 1.161 g/cm³
• Vapor Pressure: 1.45E-05mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 14.32±0.40(Predicted)
• CAS DataBase Reference: 6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLE(100510-65-4)
• EPA Substance Registry System: 6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLE(100510-65-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 100510-65-4(Hazardous Substances Data)

Usage

Uses

6-Amino-3,3-dimethylindolin-2-one is a versatile reactant used in the preparation of selective and potent aminoisoquinoline derivatives as inhibitors of mutant B-Raf pathway. It is also used in the synthesis of pentacyclic aurora kinase inhibitors.

InChI:InChI=1/C10H12N2O/c1-10(2)7-4-3-6(11)5-8(7)12-9(10)13/h3-5H,11H2,1-2H3,(H,12,13)

Upstream product

• 100510-64-3 1,3-Dihydro-3,3-dimethyl-6-nitro-2H-indol-2-one 
• 99911-10-1 2-(2-cyanopropan-2-yl)benzonitrile 
• 5488-36-8 4,4-dimethyl-4H-isoquinoline-1,3-dione 
• 14576-21-7 4,4-dimethyl-7-nitro-2H-3,4-dihydro-isoquinolin-1,3-dione 
• 826-55-1 2-methyl-2-phenylpropionic acid 
• 2901-13-5 ethyl 2-methyl-2-phenylpropionate 
• 1256633-16-5 2-(2,4-dinitro-phenyl)-2-methyl-propionic acid ethyl ester 

Downstream Products

• 1346518-86-2 C₂₆H₂₀ClFN₄O₃ 
• 1346518-87-3 C₂₇H₂₀F₄N₄O₃ 
• 1346518-88-4 C₂₇H₁₉F₅N₄O₃ 
• 1346518-89-5 C₂₇H₁₉ClF₄N₄O₃ 
• 1346518-90-8 C₂₈H₂₆N₄O₃ 
• 1346518-91-9 C₂₈H₂₅FN₄O₃ 
• 1346518-92-0 C₂₈H₂₅ClN₄O₃ 
• 1581753-44-7 N-(3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-6-yl)-2-methylisonicotinamide 
• 1346518-85-1 C₂₆H₂₀F₂N₄O₃ 
• 1346519-02-5 C₁₉H₁₅N₃O₄ 
• 1370733-36-0 C₁₉H₁₆ClN₃O₂ 
• 1370733-11-1 C₁₉H₁₆FN₃O₂ 
• 1346519-03-6 C₁₉H₁₇N₃O₂ 
• 1346518-95-3 C₂₄H₂₀ClN₅O₄ 

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