1005156-27-3Relevant academic research and scientific papers
Total synthesis of (±)-goniomitine via a formal nitrile/donor- acceptor cyclopropane [3 + 2] cyclization
Morales, Christian L.,Pagenkopf, Brian L.
, p. 157 - 159 (2008/09/18)
(Chemical Equation Presented) The total synthesis of (±)-goniomitine has been accomplished in 17 linear steps with 5.2% overall yield starting from commercially available δ-valerolactam. A synthetic highlight includes the first application of a formal [3 + 2] cycloaddition between a highly functionalized nitrile and a donor-acceptor cyclopropane to prepare an indole nucleus. The use of a microwave reactor is shown to greatly improve the reaction times for two steps.
