1005192-49-3Relevant academic research and scientific papers
Stereoselective synthesis and conformational analysis of unnatural tetrapeptides. Part 2
Almiento, Giosue M.,Balducci, Daniele,Bottoni, Andrea,Calvaresi, Matteo,Porzi, Gianni
, p. 2695 - 2711 (2008/09/17)
Stereoselective synthesis of unnatural tetrapeptides 20a and 20b, 21a and 21b and 30 and 31, containing two l-valine units and two unnatural α-amino acids (ornithine and modified aspartic acid), has been accomplished starting from the l-valine derived chiral synthon 1. Structural investigations of these non-proteinogenic peptides have been carried out on the acetamido derivatives using 1H NMR, IR spectroscopic techniques and a conformational analysis based on molecular dynamics (MD) and cluster analysis.
