1005206-16-5

Basic information

• Product Name: 4-Cyano-7H-Pyrrolo[2,3-d]pyrimidine
• Synonyms: 4-Cyano-7H-Pyrrolo[2,3-d]pyrimidine;7H-Pyrrolo[2,3-d]pyriMidine-4-carbonitrile
• CAS NO: 1005206-16-5
• Molecular Formula: C₇H₄N₄
• Molecular Weight: 144.13346
• Mol File: 1005206-16-5.mol

Chemical Properties

• Appearance: /
• Density: 1.44
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.25±0.50(Predicted)
• CAS DataBase Reference: 4-Cyano-7H-Pyrrolo[2,3-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Cyano-7H-Pyrrolo[2,3-d]pyrimidine(1005206-16-5)
• EPA Substance Registry System: 4-Cyano-7H-Pyrrolo[2,3-d]pyrimidine(1005206-16-5)

Safety Data

• Hazardous Substances Data: 1005206-16-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
4-Cyano-7H-Pyrrolo[2,3-d]pyrimidine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with improved efficacy and selectivity.
Used in Antimicrobial Applications:
4-Cyano-7H-Pyrrolo[2,3-d]pyrimidine is used as an antimicrobial agent for its potential to inhibit the growth of bacteria and other microorganisms. Its ability to target specific cellular processes makes it a valuable tool in the fight against antibiotic-resistant strains.
Used in Antiviral Applications:
4-Cyano-7H-Pyrrolo[2,3-d]pyrimidine is used as an antiviral agent, leveraging its ability to interfere with viral replication and assembly. This property makes it a promising candidate for the development of new antiviral therapies.
Used in Modulation of Ion Channels and Receptors:
4-Cyano-7H-Pyrrolo[2,3-d]pyrimidine is used as a modulator of ion channels and receptors in the central nervous system. Its interaction with these targets can lead to the development of treatments for neurological disorders and conditions.
Used in Organic Synthesis:
4-Cyano-7H-Pyrrolo[2,3-d]pyrimidine is used as a precursor in organic synthesis to produce more complex chemical structures. Its versatility in forming various derivatives makes it an essential component in the creation of advanced materials and compounds for diverse applications across industries.

InChI:InChI=1S/C7H4N4/c8-3-6-5-1-2-9-7(5)11-4-10-6/h1-2,4H,(H,9,10,11)

Upstream product

• 1086423-55-3 7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine-4-carbonitrile 
• 151-50-8 potassium cyanide 
• 3680-69-1 4-chloro-1H-pyrrolo[2,3-d]pyrimidine 

Downstream Products

• 1086423-55-3 7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine-4-carbonitrile 
• 1168106-92-0 5-bromo-7H-pyrrolo[2,3-d]pyrimidine-4-carbonitrile 
• 1086423-57-5 7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid [2-methyl-5-(3-trifluoromethyl-phenylcarbamoyl)-phenyl]-amide 
• 1086423-54-2 7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid [2-methyl-5-(3-trifluoromethyl-phenylcarbamoyl)-phenyl]-amide 
• 1086423-56-4 7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid 
• 935466-96-9 C-(7H-pyrrolo[2,3d]pyrimidin-4-yl)-methylamine dihydrochloride 

Relevant articles and documents

PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS

The present invention relates to novel compounds that are CGRP receptor antagonists, processes for their preparation, to compositions containing them and to their use in the treatment of migraine, headache, and cluster headache.

PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF

The invention provides compounds of formula (l) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of AIk, AbI, Aurora-A, B-Raf, C-Raf, Bcr-Abl, BRK, BIk, Bmx, BTK, c-Kit, c-RAF, CSK, c-SRC, EphBl, EphB2, EphB4, FLTl, Fms, Flt3, Fyn, FRK3, JAK2, KDR, Lck, Lyn, PDGFRalpha, PDGFRbeta, PKCalpha, SAPK2alpha, Src, SIK, Syk, Tie2 and TrkB kinases.

COMPOUNDS AND METHODS OF USE

Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.