1005215-22-4Relevant academic research and scientific papers
Small, potent, and selective diaryl phosphonate inhibitors for urokinase-type plasminogen activator with in vivo antimetastatic properties
Joossens, Jurgen,Ali, Omar M.,El-Sayed, Ibrahim,Surpateanu, Georgiana,Der Van Veken, Pieter,Lambeir, Anne-Marie,Setyono-Han, Buddy,Foekens, John A.,Schneider, Anneliese,Schmalix, Wolfgang,Haemers, Achtel,Augustyns, Koen
, p. 6638 - 6646 (2008/09/17)
A set of small nonpeptidic diaryl phosphonate inhibitors was prepared. Some of these inhibitors show potent and highly selective irreversible uPA inhibition. The biochemical and modeling data prove that the combination of a benzylguanidine moiety with a d
