100527-50-2

Usage

Type of compound

quinazolin-4(3H)-thione derivative

Type of compound

heterocyclic organic compound

Substitution

bromophenyl at the 2-position

Potential applications

medicinal chemistry and pharmaceutical research

Possible properties

biological activities and therapeutic properties

Value in synthesis

valuable building block for the synthesis of novel compounds with potential pharmacological activities

InChI:InChI=1/C14H9BrN2S/c15-10-7-5-9(6-8-10)13-16-12-4-2-1-3-11(12)14(18)17-13/h1-8H,(H,16,17,18)

Upstream product

• 83800-88-8 2-(4-bromophenyl)-3H-quinazolin-4-one 
• 28144-70-9 anthranilic acid amide 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 1448068-47-0 C₁₅H₁₀BrN₅ 
• 371955-33-8 C₁₄H₁₁BrN₄ 

Relevant academic research and scientific papers

Synthesis and anticonvulsant activity evaluation of 5-Phenyl-[1,2,4] triazolo[4,3-c]quinazolin-3-amines

In the present study we describe the syntheses and anticonvulsant activity evaluation of 5-phenyl-[1,2,4]triazolo[4,3-c]quinazolin-3-amine derivatives. Their anticonvulsant activity and neurotoxicity were evaluated by the maximal electroshock seizure test (MES) and the rotarod test, respectively. The majority of the compounds prepared were effective in the MES screens at a dose level of 100 mg/kg. Of these compounds, the most promising was compound 8h, which showed an ED50 value of 27.4 mg/kg and a protective index (PI) value of 5.8. These values were superior to those provided by valproate (ED50 and PI values of 272 and 1.6, respectively) in the MES test in mice. As well as its anti-MES efficacy, the potencies of compound 8h against seizures induced by pentylenetetrazole and thiosemicarbazide were also established, with the results suggesting that the GABAergic system-mediated mechanisms might be involved in its anticonvulsant activity. Copyright