1005339-34-3Relevant academic research and scientific papers
Regulation of cyclization for the stereoselective synthesis of substituted tetrahydrofurans and tetrahydrooxepines
Kim, Sang-Hoon,Oh, Seung-Ju,Ho, Pil-Su,Kang, Sin-Cheol,O, Kyung-Jin,Yu, Chan-Mo
, p. 265 - 268 (2008)
(Chemical Equation Presented) Dramatic solvent effect is observed during the cyclization of 1. Synthesis of 2 is achieved from the reaction of 1 with a hexamethylditin-catalyzed palladium complex followed by aldehydes in the presence of TMSOTf in THF, whereas 3 is formed in CH2Cl2. The method described herein is successful with various substrates 1 in good yields and high levels of diastereoselectivity.
