1005344-35-3Relevant academic research and scientific papers
Concise total synthesis of botryolide B
Mohapatra, Debendra K.,Umamaheshwar, Gonela,Rao, M. Mallikarjuna,Umadevi, Deivasigamani,Yadav, Jhillu S.
, p. 8335 - 8340 (2014)
An efficient total synthesis of botryolide B was achieved in 9 longest linear steps with 22% overall yield via esterification of a carboxylic acid with an alcohol fragment and a ring closing metathesis (RCM) reaction as pivotal steps to construct the macrolactone ring system. Our novel approach for the synthesis of the 2-alkene-1,5-diol fragment was achieved by a ring closing metathesis reaction followed by a reductive opening strategy, whereas the carboxylic acid fragment was accessed from commercially available (R)-(+)-α-hydroxy-γ-butyrolactone in three steps.
Total synthesis of decarestrictine i and botryolide B via RCM protocol
Radha Krishna, Palakodety,Rao, T. Jagannadha
supporting information; experimental part, p. 3130 - 3132 (2010/08/21)
A convergent stereoselective total synthesis of decarestrictine I (1) and botryolide B (1a) invoking a common synthetic strategy is reported. The key steps are: ring-closing metathesis of epoxy dienoic esters obtained through the Yamaguchi esterification
A concise stereoselective total synthesis of Botryolide B
Reddy, B. Chennakesava,Meshram
scheme or table, p. 4020 - 4022 (2010/08/07)
The first total synthesis of Botryolide B is described from easily accessible starting materials. The synthetic strategy involves Jacobsen resolution, Sharpless epoxidation, Swern oxidation, Yamaguchi reaction, and ring closing metathesis (RCM).
