1005346-96-2

Basic information

• Product Name: 2-Formyl-4,5-dimethoxyphenylboronic acid
• Synonyms: 2-Formyl-4,5-dimethoxyphenylboronic acid
• CAS NO: 1005346-96-2
• Molecular Formula: C₉H₁₁BO₅
• Molecular Weight: 209.99164
• Mol File: 1005346-96-2.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 2-Formyl-4,5-dimethoxyphenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Formyl-4,5-dimethoxyphenylboronic acid(1005346-96-2)
• EPA Substance Registry System: 2-Formyl-4,5-dimethoxyphenylboronic acid(1005346-96-2)

Safety Data

• Hazardous Substances Data: 1005346-96-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-Formyl-4,5-dimethoxyphenylboronic acid is used as a reagent in organic synthesis for its ability to form stable complexes with diols and amines. This property makes it a valuable component in cross-coupling reactions and other organic transformations, contributing to the development of new chemical compounds and materials.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-Formyl-4,5-dimethoxyphenylboronic acid is utilized as a key intermediate in the synthesis of potential drug candidates. Its versatile reactivity and compatibility with a wide range of functional groups make it a promising building block for the development of new drugs with novel therapeutic properties.
Used in Drug Development:
2-Formyl-4,5-dimethoxyphenylboronic acid has potential applications in the development of new drugs and materials. Its unique structure and reactivity allow for the creation of innovative molecules with potential therapeutic benefits. Researchers can leverage its properties to design and synthesize compounds with improved pharmacological profiles, such as enhanced potency, selectivity, and bioavailability.

Upstream product

• 121-43-7 Trimethyl borate 
• 70461-33-5 2-bromo-4,5-dimethoxybenzaldehyde dimethyl acetal 
• 1098755-60-2 4,5-dimethoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 5419-55-6 Triisopropyl borate 

Downstream Products

• 29237-14-7 [4,5,4′,5′-tetramethoxybiphenyl]-2,2′-dicarboxaldehyde 

Relevant articles and documents

Design and enantioselective synthesis of 3-(α-acrylic acid) benzoxaboroles to combat carbapenemase resistance

Chiral 3-substituted benzoxaboroles were designed as carbapenemase inhibitors and efficiently synthesisedviaasymmetric Morita-Baylis-Hillman reaction. Some of the benzoxaboroles were potent inhibitors of clinically relevant carbapenemases and restored the activity of meropenem in bacteria harbouring these enzymes. Crystallographic analyses validate the proposed mechanism of binding to carbapenemases,i.e.in a manner relating to their antibiotic substrates. The results illustrate how combining a structure-based design approach with asymmetric catalysis can efficiently lead to potent β-lactamase inhibitors and provide a starting point to develop drugs combatting carbapenemases.

Sustainable Passerini-tetrazole three component reaction (PT-3CR): selective synthesis of oxaborol-tetrazoles

A sustainable catalyst- and solvent-free Passerini-tetrazole three component reaction (PT-3CR) has been developed for the selective synthesis of benzoxaborol-tetrazoles for the first time. The synthetic potential of oxaboroles was demonstrated towards various functionalized tetrazoles, which are otherwise difficult to achieve through conventional PT-3CR from aromatic aldehydes/ketones. The reaction features high practicality, broad substrate scope and excellent yields (80-98%). Preliminary results of the asymmetric PT-3CR are also shown for the synthesis of chiral benzoxaboroles.

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