1005346-96-2

Basic information

• Product Name: 2-Formyl-4,5-dimethoxyphenylboronic acid
• Synonyms: 2-Formyl-4,5-dimethoxyphenylboronic acid
• CAS NO: 1005346-96-2
• Molecular Formula: C₉H₁₁BO₅
• Molecular Weight: 209.99164
• Mol File: 1005346-96-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 2-Formyl-4,5-dimethoxyphenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Formyl-4,5-dimethoxyphenylboronic acid(1005346-96-2)
• EPA Substance Registry System: 2-Formyl-4,5-dimethoxyphenylboronic acid(1005346-96-2)

Safety Data

• Hazardous Substances Data: 1005346-96-2(Hazardous Substances Data)

Usage

General Description

2-Formyl-4,5-dimethoxyphenylboronic acid, also known as 2-Formyl-4,5-dimethoxybenzeneboronic acid, is a chemical compound with the molecular formula C10H13BO5. It is a boronic acid derivative that contains a formyl group and two methoxy groups attached to a phenyl ring. 2-Formyl-4,5-dimethoxyphenylboronic acid is commonly used as a reagent in organic synthesis and pharmaceutical research. It is known for its ability to form stable complexes with diols and amines, making it useful in cross-coupling reactions and other organic transformations. 2-Formyl-4,5-dimethoxyphenylboronic acid has potential applications in the development of new drugs and materials due to its versatile reactivity and compatibility with a wide range of functional groups.

Upstream product

• 5419-55-6 Triisopropyl borate 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 121-43-7 Trimethyl borate 
• 70461-33-5 2-bromo-4,5-dimethoxybenzaldehyde dimethyl acetal 
• 1098755-60-2 4,5-dimethoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 

Downstream Products

• 29237-14-7 [4,5,4′,5′-tetramethoxybiphenyl]-2,2′-dicarboxaldehyde 

Relevant articles and documents

Design and enantioselective synthesis of 3-(α-acrylic acid) benzoxaboroles to combat carbapenemase resistance

Chiral 3-substituted benzoxaboroles were designed as carbapenemase inhibitors and efficiently synthesisedviaasymmetric Morita-Baylis-Hillman reaction. Some of the benzoxaboroles were potent inhibitors of clinically relevant carbapenemases and restored the activity of meropenem in bacteria harbouring these enzymes. Crystallographic analyses validate the proposed mechanism of binding to carbapenemases,i.e.in a manner relating to their antibiotic substrates. The results illustrate how combining a structure-based design approach with asymmetric catalysis can efficiently lead to potent β-lactamase inhibitors and provide a starting point to develop drugs combatting carbapenemases.

Synthesis of naphthalene ring derivatives and Benzoheterocycles the method of the compound

The invention discloses a method for synthesizing naphthalene derivative and benzo-heterocycle compounds. The method is realized by promoting a reaction similar to Mortia-Baylis-Hillman between aryl aldehyde having alpha, beta-unsaturated ester on ortho-position and ketone compounds under the catalysis action of tertiary amine and tertiary phosphine organic small molecular catalysts, so as to remove a molecule of H2O, so that the naphthalene derivative or benzo-heterocycle compounds are generated. The method disclosed by the invention is simple in operation step, cheap and easily available in adopted catalysts and harmless to environment, and a series of naphthalene derivative and benzo-heterocycle compounds are synthesized with relatively high yield.