1005403-39-3Relevant academic research and scientific papers
METHOD OF PRODUCING CRYSTAL OF [1-(4-{3-[(2R)-2-METHYLPYRROLIDIN-1-YL]PROPOXY}PHENYL)-1H-PYRAZOL-4-YL](MORPHOLIN-4-YL)METHANONE
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, (2019/08/08)
PROBLEM TO BE SOLVED: To provide a novel method of producing a crystal of [1-(4-{3-[(2R)-2-methylpyrrolidin-1-yl]propoxy}phenyl)-1H-pyrazol-4-yl](morpholin-4-yl)methanone, which exhibits H3 receptor antagonism. SOLUTION: The invention provides a method of producing a crystal of a compound represented by formula [1] in the figure, which is crystallized using an ether based solvent. (X1 is methanesulfonyloxy, trifluoromethanesulfonyloxy, or p-toluenesulfonyloxy; and X2 is a halogen atom.) SELECTED DRAWING: Figure 9 COPYRIGHT: (C)2019,JPOandINPIT
Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl) propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): A potent, selective histamine H3 receptor inverse agonist
Hudkins, Robert L.,Raddatz, Rita,Tao, Ming,Mathiasen, Joanne R.,Aimone, Lisa D.,Becknell, Nadine C.,Prouty, Catherine P.,Knutsen, Lars J. S.,Yazdanian, Mehran,Moachon, Gilbert,Ator, Mark A.,Mallamo, John P.,Marino, Michael J.,Bacon, Edward R.,Williams, Michael
experimental part, p. 4781 - 4792 (2011/09/21)
Optimization of a novel series of pyridazin-3-one histamine H3 receptor (H3R) antagonists/inverse agonists identified 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (8a, CEP-26401; irdabisant) as a lead candid
