1005407-84-0Relevant academic research and scientific papers
Remote trifluoromethylthiolation of alcohols under visible light
Barday, Manuel,Blieck, Remi,Ruyet, Louise,Besset, Tatiana
, (2020)
An unprecedented remote and regioselective trifluoromethylthiolation reaction of alcohols was developed. Under mild conditions, a panel of free-alcohols was selectively functionalized with TolSO2SCF3 reagent as the SCF3 source in the presence of hypervalent iodide (PIDA) under blue light irradiation. This approach offered an operationally simple tool for the construction of a challenging C(sp3)-SCF3 bond at the δ-position of an alcohol by C(sp3)-H bond functionalization. Initial mechanistic studies suggested a radical pathway.
CHEMICAL COMPOUNDS
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Page/Page column 90, (2008/06/13)
The invention provides compounds formula I, their preparation, and their use as pharmaceutically active immunosuppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activated immune system, a
