1005451-89-7Relevant academic research and scientific papers
Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents
Biava, Mariangela,Porretta, Giulio C.,Poce, Giovanna,Supino, Sibilla,Manetti, Fabrizio,Forli, Stefano,Botta, Maurizio,Sautebin, Lidia,Rossi, Antonietta,Pergola, Carlo,Ghelardini, Carla,Norcini, Monica,Makovec, Francesco,Giordani, Antonio,Anzellotti, Paola,Cirilli, Roberto,Ferretti, Rosella,Gallinella, Bruno,Torre, Francesco La,Anzini, Maurizio,Patrignani, Paola
, p. 8072 - 8081 (2008/12/23)
Following our previous research on anti-inflammatory drugs (NSAIDs), we report here the synthesis of chiral 1,5-diarylpyrroles derivatives that were characterized for their in vitro inhibitory effects toward cyclooxygenase (COX) isozymes. Analysis of enzy
