1005451-94-4

Upstream product

• 853055-06-8 ethyl 2-[1-phenyl-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]acetate 

Downstream Products

• 1429808-15-0 2-(2-methyl-5-(4-(methylsulfonyl)phenyl)-1-phenyl-1H-pyrrol-3-yl)ethyl-1H-imidazole-1-carboxylate 
• 1363374-62-2 2-(nitrooxy)-[2-[(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]acetate 
• 1429808-13-8 2-(2-methyl-5-(4-(methylsulfonyl)phenyl)-1-phenyl-1H-pyrrol-3-yl)ethyl methanesulfonate 
• 1363374-64-4 2-(2-methyl-5-(4-(methylsulfonyl)phenyl)-1-phenyl-1H-pyrrol-3-yl)ethyl 4-(nitrooxy)butanoate 
• 1386390-35-7 2-methyl-5-(4-(methylsulfonyl)phenyl)-1-phenyl-3-(2-((tetrahydro-2H-pyran-2-yloxy)propoxy)ethyl)-1H-pyrrole 
• 1363375-68-1 1-phenyl-2-methyl-5-(4-methylsulphonylphenyl)-3-[2-(2-(tetrahydro-2H-pyran-2-yl)oxy)ethoxy]ethyl-1H-pyrrole 
• 1363375-22-7 2-[2-[1-phenyl-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]ethoxy]ethanol 
• 1429808-14-9 2-(2-methyl-5-(4-(methylsulfonyl)phenyl)-1-phenyl-1H-pyrrol-3-yl)ethyl nitrate 
• 1363375-26-1 1-phenyl-2-methyl-5-(4-methylsulphonylphenyl)-3-(2-propyloxyl)ethyl-1H-pyrrole 
• 1363375-67-0 2-(2-(2-methyl-5-(4-(methylsulfonyl)phenyl)-1-phenyl-1H-pyrrol-3-yl)ethoxy)ethyl methanesulfonate 
• 1363375-75-0 3-(2-(2-methyl-5-(4-(methylsulfonyl)phenyl)-1-phenyl-1H-pyrrol-3-yl)ethoxy)propyl methanesulfonate 
• 1363374-44-0 2-[2-[1-phenyl-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]ethoxy]ethyl nitrate 
• 1363374-49-5 3-[2-[2-(1-phenyl-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]propyl nitrate 
• 1429808-16-1 2-(2-methyl-5-(4-(methylsulfonyl)phenyl)-1-phenyl-1H-pyrrol-3-yl)ethyl-3-(nitrooxy)propyl carbonate 

Relevant academic research and scientific papers

Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity

A series of substituted 1,5-diarylpyrrole-3-alkoxyethyl ethers (6, 7, and 8) has been synthesized with the aim to assess if in the previously reported 1,5-diarylpyrrole derivatives (5) the replacement of the acetic ester moiety with an alkoxyethyl group s

3-SUBSTITUTED-1,5-DIARLY-2-ALKYL-PYRROLES HIGHLY SELECTIVE AND ORALLY EFFECTIVE COX-2 INHIBITORS

This invention relates to 3-substituted-l, 5-diaryl-2-alkyl- pyrroles of Formula (I), pharmaceutical compositions containing them, and to their use for the pharmacological treatment of pain and COX-2 over-activation associated disorders. Compounds of this