1005457-03-3Relevant articles and documents
Convenient one-pot synthesis of 2,2-bis-(4-hydroxyphenyl)-cyclopentanone
Jai, Woong Seo,Hee, Jun Kim,Byoung, Se Lee,Katzenellenbogen, John A.,Dae, Yoon Chi
, p. 715 - 718 (2008/09/18)
(Chemical Equation Presented) 2,2-Bis-(4-hydroxyphenyl)-cyclopentanone (3a) was unexpectedly obtained in 76% yield from a reductive coupling reaction of 4,4′-dihydroxybenzophenone (1a) and cyclobutanone with TiCl4 and Zn. Further optimization showed that catechol as an external ligand and a hydroxy group on benzophenone facilitated the generation of a quinonemethide (intermediate II) that is involved in the pinacol-type rearrangement of intermediate I to give the rearranged product.