1005485-30-2Relevant academic research and scientific papers
Modification on the O-glucoside of Sergliflozin-A: A new strategy for SGLT2 inhibitor design
Cao, Xuefeng,Zhang, Wenpeng,Yan, Xu,Huang, Zhi,Zhang, Zhenqing,Wang, Peng,Shen, Jie
supporting information, p. 2170 - 2173 (2016/04/20)
Poor pharmacokinetic stability is one of the issues of O-glucoside SGLT2 inhibitors in clinical trials, hence C-glucoside inhibitors have been developed and extensively applied. Herein, we provided an alternative approach to improve the pharmacokinetic st
BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE
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Page/Page column 76, (2009/05/29)
The present invention relates to a benzylphenyl glucopyranoside derivative having an excellent inhibitory effect on human SGLT1 and/or SGLT2 activity. There is provided a compound or a pharmacologically acceptable salt thereof represented by the following general formula (I): wherein R1 represents a hydrogen atom, an amino group, a hydroxy C1-C6 alkyl group, etc.; R2 represents a hydrogen atom, etc.; R3 represents a C1-C6 alkyl group, a hydroxy C1-C6 alkyl group, etc.; R4 represents a hydrogen atom, a C2-C7 acyl group, etc.; R5, R6, R7, and R8 are the same or different and each represents a hydrogen atom or a C1-C6 alkyl group, provided that R5, R6, R7 and R8 are not hydrogen atoms at the same time; n is 0 to 4; and X is CH or N.
