1005500-80-0

Basic information

• Product Name: N-((4-chlorophenyl)ethynyl)-N,4-dimethylbenzenesulfonamide
• Synonyms: N-((4-chlorophenyl)ethynyl)-N,4-dimethylbenzenesulfonamide
• CAS NO: 1005500-80-0
• Molecular Weight: 319.812
• Mol File: 1005500-80-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-((4-chlorophenyl)ethynyl)-N,4-dimethylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-((4-chlorophenyl)ethynyl)-N,4-dimethylbenzenesulfonamide(1005500-80-0)
• EPA Substance Registry System: N-((4-chlorophenyl)ethynyl)-N,4-dimethylbenzenesulfonamide(1005500-80-0)

Safety Data

• Hazardous Substances Data: 1005500-80-0(Hazardous Substances Data)

Upstream product

• 33491-02-0 1-chloro-4-(chloroethynyl)benzene 
• 640-61-9 N-methyl-p-toluenesulfonylamide 
• 7632-59-9 (Z)-1-chloro-4-(1,2-dichlorovinyl)benzene 
• 5263-17-2 4-chloro-1-(2,2-dichloroethenyl)benzene 

Downstream Products

• 1005500-88-8 (E)-2-p-chlorophenyl-1-[methyl(p-tolylsulfonyl)amino]ethenyl diphenyldithiophosphinate 

Relevant articles and documents

Transition-Metal-Free One-Step Synthesis of Ynamides

A robust transition-metal-free one-step strategy for the synthesis of ynamides from sulfonamides and (Z)-1,2-dichloroalkenes or alkynyl chlorides is presented. This method is not only effective for internal ynamides but also amenable for terminal ynamides. Various functional groups, even the vinyl moiety, are compatible, and thus, this strategy offers the opportunity for further functionalization.

A Robust One-Step Approach to Ynamides

A robust one-step synthetic strategy for ynamide with cheap and easily available stock chemicals vinyl dichlorides and electron deficient amides as the starting material is described. In the absence of transition-metal catalyst, the reaction proceeds under mild reaction conditions in open air and thus rendering a convenient operation. This strategy is not only suitable for both terminal and internal ynamide synthesis but also amenable for large-scale preparation. Broad substrate scopes with respect to vinyl dichloride as well as electron-deficient amide were observed.