100551-53-9

Usage

Uses

Used in Organic Synthesis:
N~2~-benzoyl-N-cyano-L-leucinamide is used as a reagent and intermediate in organic synthesis for its capacity to form stable and reactive intermediates, facilitating the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N~2~-benzoyl-N-cyano-L-leucinamide is utilized as a key intermediate in the preparation of various pharmaceuticals. Its role in creating stable intermediates is crucial for the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
N~2~-benzoyl-N-cyano-L-leucinamide also finds application in the agrochemical industry, where it serves as an intermediate in the synthesis of agrochemicals, contributing to the development of effective pesticides and other agricultural chemicals.
Used in the Development of New Materials:
Beyond its applications in synthesis, N~2~-benzoyl-N-cyano-L-leucinamide is used as a building block in the creation of new materials, indicating its versatility and potential in material science for developing innovative products with unique properties.
Used in the Development of Bioactive Compounds:
Furthermore, N~2~-benzoyl-N-cyano-L-leucinamide is employed in the development of bioactive compounds, which are essential in various fields such as medicine, where they can be used to target specific biological processes or pathways.

Upstream product

• 31202-38-7 N-benzoyl-L-leucine N-hydroxysuccinimide ester 
• 420-04-2 CYANAMID 
• 1466-83-7 N-benzoyl-L-leucine 

Relevant academic research and scientific papers

Acylated cyanamide composition for treating ethanol ingestion

Acylated cyanamide compounds useful for ethanol deterrence of the formula RCONHCN, wherein R is a lipophilic acyl group or is derived from an (N-substituted)-alpha-aminoacyl group.

Acyl, N-Protected α-Aminoacyl, and Peptidyl Derivatives as Prodrug Forms of the Alcohol Deterrent Agent Cyanamide

Cyanamide , a potent aldehyde dehydrogenase (AlDH) inhibitor that is used therapeutically as an alcohol deterrent agent, is known to be rapidly metabolized and excreted in the urine as acetylcyanamide (1). On the basis of our observation that 1 is deacetylated to cyanamide in vivo, albeit very slightly, thereby serving as a precursor or prodrug form of the latter, several acyl derivatives of cyanamide were synthesized specifically as prodrugs, including benzoylcyanamide (2), pivaloylcyanamide (3), and 1-adamantoylcyanamide (4), as well as long- and medium-chain fatty acyl derivatives such as palmitoyl- (6), stearoyl- (7), and n-butyrylcyanamide (5). N-Protected α-aminoacyl and peptidyl derivatives of cyanamide were also synthesized, and these include N-carbobenzoxyglycyl- (10), hippuryl- (13), N-benzoyl-L-leucyl- (14), N-carbobenzoxyglycyl-L-leucyl- (18), N-carbobenzoxy-L-pyroglutamyl- (22), L-pyroglutamyl-L-leucyl- (19), and L-pyroglutamyl-L-phenylalanylcyanamide (20). All of these prodrugs of cyanamide raised ethanol-derived blood acetaldehyde levels in rats significantly over controls 3h after ip drug administration, and some of these were still capable of elevating blood acetaldehyde 16 h post drug administration. A selected group of cyanamide prodrugs were also evaluated by the oral route of administration and showed nearly equivalent activity as the ip route in elevating ethanol-derived blood acetaldehyde. These results suggest potential utility of these prodrugs as deterrent agents for the treatment of alcoholism.