100557-82-2

Upstream product

• 941567-71-1 (1R,2S,3R,4S)-bicyclo[2.2.1]hept-5-ene-2,3-dimethanol 
• 64550-47-6 (3aS*,4R*,7S*,7aR*)-3a,4,7,7a-tetrahydro-4,7-methanoisobenzofuran-1(3H)-one 

Downstream Products

• 109586-66-5 Methyl-6-<(2-endo,3-exo)-3-<<2-(2-chlorphenyl)ethyl>carbamoyl>bicyclo<2.2.1>hept-2-yl>hexanoat 
• 109586-67-6 Methyl-6-<(2-endo,3-exo)-3-<<2-(3-methoxyphenyl)ethyl>carbamoyl>bicyclo<2.2.1>hept-2-yl>hexanoat 
• 109586-69-8 6-<(2-endo,3-exo)-3-<<2-(2-Chlorphenyl)ethyl>carbamoyl>bicyclo<2.2.1>hept-2-yl>hexansaeure 
• 109586-70-1 6-<(2-endo,3-exo)-3-<<2-(3-Methoxyphenyl)ethyl>carbamoyl>bicyclo<2.2.1>hept-2-yl>hexansaeure 
• 100557-78-6 Methyl-6-<(2-endo,3-exo)-3-<<2-(3-chlorphenyl)ethyl>carbamoyl>bicyclo<2.2.1>hept-2-yl>hexanoat 
• 100557-81-1 6-<(2-endo,3-exo)-3-<<2-(3-Chlorphenyl)ethyl>carbamoyl>bicyclo<2.2.1>hept-2-yl>hexansaeure 

Relevant academic research and scientific papers

OXIDATION OF ALCOHOLS USING DIMETHYL SULFOXIDE AND TRICHLORMETHYL CHLOROFORMATE

Treatment of structurally diverse alcohols with dimethyl sulfoxide in the presence of trichloromethyl chloroformate (phosgene dimer) and triethylamine efficiently afforded the corresponding aldehydes or ketones in excellent yields.

6-(3-Carbamoylbicyclohept-2-yl)hexanoic Acids, a New Class of TxA2 Antagonists

The synthesis of prostanoids 20-27, 40a, b, and 45a, b starting from the educts 1a, b, and 31 is described.Configurational changes concerning to the positions 2 and 3 of the bicyclic system were proofed by 13C-NMR spectroscopy and were also used for the preparation of the four exo/endo derivatives. 25 and 26 are potent TxA2 antagonists.