10056-69-6

Usage

Physical state

Colorless liquid 2,2,2-Trifluoro-N-propylacetamide is a liquid without any color, which is a common characteristic of many chemical compounds.

Industrial applications

Pharmaceutical and agrochemical production 2,2,2-Trifluoro-N-propylacetamide is used in the manufacturing of various pharmaceuticals and agrochemicals, indicating its versatility and importance in these industries.

Stability

High 2,2,2-Trifluoro-N-propylacetamide is known for its high stability, making it a desirable ingredient in many products as it is less likely to break down or react unpredictably.

Toxicity

Low The compound has low toxicity, which is beneficial for its use in various applications, as it minimizes potential harm to humans and the environment.

Chemical reactivity

Wide range 2,2,2-Trifluoro-N-propylacetamide can participate in a variety of chemical processes due to its wide range of reactivity, making it a valuable compound in the field of chemistry.

Precautions

Prolonged exposure to high concentrations can have adverse effects on human health While 2,2,2-Trifluoro-N-propylacetamide has low toxicity, it is still important to handle it with care and avoid prolonged exposure to high concentrations to prevent any potential harm to human health.

Upstream product

• 107-10-8 propylamine 
• 407-25-0 trifluoroacetic anhydride 
• 109317-75-1 4-trifluoroacetyl-2,3-dihydrofuran 

Downstream Products

• 376596-67-7 2,2,2-trifluoro-N-[3-(5-methyl-1,2,4-oxadiazol-3-yl)benzyl]-N-propylacetamide 

Relevant academic research and scientific papers

Photoredox-Catalyzed Site-Selective α-C(sp3)?H Alkylation of Primary Amine Derivatives

The synthetic utility of tertiary amines to oxidatively generate α-amino radicals is well established, however, primary amines remain challenging because of competitive side reactions. This report describes the site-selective α-functionalization of primary amine derivatives through the generation of α-amino radical intermediates. Employing visible-light photoredox catalysis, primary sulfonamides are coupled with electron-deficient alkenes to efficiently and mildly construct C?C bonds. Interestingly, a divergence between intermolecular hydrogen-atom transfer (HAT) catalysis and intramolecular [1,5] HAT was observed through precise manipulation of the protecting group. This dichotomy was leveraged to achieve excellent α/δ site-selectivity.

Conformations and Vibrational Dynamics of Six Monoalkyltrifluoroacetamides. Low-Resolution Microwave and Gas-Phase NMR Spectroscopic Studies

Low resolution microwave spectra of six N-alkyltrifluoroacetamides (F3C(O)NHR; r = CH3, C2H5, i-C3H7, n-C3H7, i-C4H9, t-C4H9) display band series consistent with a single species having the R group oriented syn to the carbonyl moiety. 5JH-F coupling constats observed in gas- and liquid-phase NMR spectra of N-methyltrifluoroacetamide confirm this assignment.For each molecule the observed rotational constats, anomalously broad microwave bandwidths, and absence of resolvable fine structure are consistent with predicted effects of rapid intramolecular vibrational redistribution (IVR).Sufficient state density for IVR in these molecules occurs at low internal energies.

Convenient one-pot synthesis of N-substituted 3-trifluoroacetyl pyrroles

A new one-pot strategy for the synthesis of a series of new N-substituted 3-trifluoroacetyl pyrroles is presented. These compounds were obtained by the reaction of 3-trifluoroacetyl-4,5-dihydrofuran with primary amines, which generated 1,1,1-trifluoro-3-(2-hydroxyethyl)-4-alkylaminobut-3-en-2-one intermediates. In most cases these intermediates were not stable enough to be isolated. Thus, in the same reaction vessel they were directly submitted to oxidation with PCC (Corey's reagent) to furnish 1,1,1-trifluoro-3-(2-ethanal)-4- alkylaminobut-3-en-2-ones, which under reflux underwent intramolecular cyclization to give the desired N-substituted 3-trifluoroacetyl pyrroles, in moderate yields. All of these pyrroles were tested against pan-susceptible Mycobacterium tuberculosis H37Rv and clinical isolates INH- and RMP-resistant strain and some of these compounds showed significant in vitro antimicrobial activity. Georg Thieme Verlag Stuttgart.

Carbamic acid esters as inhibitors of factor xa

Novel compounds of the formula I in which R, R1 and R2 are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic illnesses.

Urethane derivatives

The invention relates to novel compounds of formula (I), wherein R, R1 and R2 have the meaning as cited claim 1. According to the invention, the compounds are inhibitors of the coagulation factors Xa and VIIa and can be used for treating thrombosis, myocardial infarct, arteriosclerosis, inflammation, apoplexy, angina pectoris, restenosis post-angioplasty, intermittent claudication, tumours, tumour related illnesses and/or tumour metastases.

Acetamide derivatives and the use thereof as inhibitors of coagulation factors xa and viia

Novel compounds of the formula I, in which R, R1 and R2 are as defined in patent claim 1, are inhibitors of coagulation factor Xa and VIIa and can be employed for the treatment of thromboses, myocardial infarction, arteriosclerosis, inflammation, apoplexis, angina pectoris, restenosis after angioplasty, claudicatio intermittens, tumours, tumour diseases and/or tumour metastases.