1005640-51-6Relevant articles and documents
Design, Synthesis and Pharmacological Evaluation of Novel Hsp90N-terminal Inhibitors Without Induction of Heat Shock Response
Liu, Peng,Chen, Xiangling,Zhu, Jianming,Li, Bo,Chen, Zhaoqiang,Wang, Guimin,Sun, Haiguo,Xu, Zhijian,Zhao, Zhixin,Zhou, Chen,Xie, Chengying,Lou, Liguang,Zhu, Weiliang
, p. 344 - 353 (2019)
Heat shock protein 90 (Hsp90) is a potential oncogenic target. However, Hsp90 inhibitors in clinical trial induce heat shock response, resulting in drug resistance and inefficiency. In this study, we designed and synthesized a series of novel triazine der