100570-24-9

Basic information

• Product Name: (R)-1-(3,4-Dimethoxyphenyl)ethylamine
• Synonyms: (R)-1-(3,4-DIMETHOXYPHENYL)ETHANAMINE;(R)-1-(3,4-DIMETHOXYPHENYL)ETHYLAMINE;(R)-1-(3,4-Dimethoxyphenyl)ethylamine, ChiPros 98%, ee 98+%;Benzenemethanamine, 3,4-dimethoxy-α-methyl-, (αR)-;Benzenemethanamine, 3,4-dimethoxy-.alpha.-methyl-, (.alpha.R)-;4-diMethoxy-a-Methyl-;(R)-1-(3,4-DiMethoxyphenyl)ethylaMine, ChiPros|r, 98%, ee 98+%;(R)-3,4-Dimethoxy-α-methylbenzylamine
• CAS NO: 100570-24-9
• Molecular Formula: C₁₀H₁₅NO₂
• Molecular Weight: 181.23
• Product Categories: API intermediates
• Mol File: 100570-24-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 120°C/1mm
• Flash Point: 120°C/1mm
• Appearance: /
• Density: 1.037 g/cm³
• Vapor Pressure: 0.00623mmHg at 25°C
• Refractive Index: 1.515
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.18±0.10(Predicted)
• Sensitive: Air Sensitive
• BRN: 8616003
• CAS DataBase Reference: (R)-1-(3,4-Dimethoxyphenyl)ethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(3,4-Dimethoxyphenyl)ethylamine(100570-24-9)
• EPA Substance Registry System: (R)-1-(3,4-Dimethoxyphenyl)ethylamine(100570-24-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-38-41
• Safety Statements: 26-37/39
• RIDADR: UN2735
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 100570-24-9(Hazardous Substances Data)

Usage

General Description

(R)-1-(3,4-Dimethoxyphenyl)ethylamine, also known as DMPEA, is a chemical compound with the molecular formula C10H15NO2. It is an organic amine that contains a phenethylamine moiety, making it structurally similar to the neurotransmitter dopamine. DMPEA is commonly found in various plants and has been identified as a psychoactive compound with potential stimulant effects on the central nervous system. It has been found in trace amounts in certain dietary supplements and is also considered a precursor to the production of illegal drugs such as methamphetamine and MDMA. However, its physiological effects and safety profile in humans are not fully understood, and further research is needed to determine its potential uses and risks.

InChI:InChI=1/C10H15NO2/c1-7(11)8-4-5-9(12-2)10(6-8)13-3/h4-7H,11H2,1-3H3/t7-/m1/s1

Upstream product

• 50919-08-9 1-(3',4'-Dimethoxyphenyl)ethylamine 
• 293307-92-3 [(R)-1-(3,4-Dimethoxy-phenyl)-ethyl]-(4-methoxy-naphthalen-1-yl)-amine 
• 108-24-7 acetic anhydride 

Downstream Products

• 1190089-37-2 C₁₈H₁₇NO₅ 
• 875656-36-3 N-(4-chloro-3-trifluoromethylphenyl)-2-[(R)-1-(3,4-dimethoxyphenyl)-ethylamino]-acetamide 

Relevant articles and documents

Nonpeptide urotensin-II receptor antagonists: A new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits

We have discovered two related chemical series of nonpeptide urotensin-II (U-II) receptor antagonists based on piperazino-phthalimide (5 and 6) and piperazino-isoindolinone (7) scaffolds. These structure types are distinctive from those of U-II receptor antagonist series reported in the literature. Antagonist 7a exhibited single-digit nanomolar potency in rat and human cell-based functional assays, as well as strong binding to the human U-II receptor. In advanced pharmacological testing, 7a blocked the effects of U-II in vitro in a rat aortic ring assay and in vivo in a rat ear-flushmodel. Adiscussion of U-II receptor antagonist pharmacophores is presented, and a specifically defined model is suggested from tricycle 13, which has a high degree of conformational constraint.

A facile and efficient asymmetric synthesis of (+)-salsolidine

A three-key step methodology involving a highly selective asymmetric addition of an organolithium reagent to an N-naphthalenylimine, cyclization and oxidative removal of the N-naphthalenyl group provided a facile and efficient synthetic way to (+)-salsolidine. (C) 2000 Elsevier Science Ltd.