1005775-72-3Relevant academic research and scientific papers
Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors
Terao, Yoshito,Suzuki, Hideo,Yoshikawa, Masato,Yashiro, Hiroaki,Takekawa, Shiro,Fujitani, Yasushi,Okada, Kengo,Inoue, Yoshihisa,Yamamoto, Yoshio,Nakagawa, Hideyuki,Yao, Shuhei,Kawamoto, Tomohiro,Uchikawa, Osamu
supporting information, p. 7326 - 7329 (2013/02/21)
Imidazo[1,2-a]pyridine derivatives were designed, synthesized, and evaluated as inhibitors of the apoptosis signal-regulating kinase 1 (ASK1). These were based on a benzothiazole derivative that was discovered from high-throughput screening of our compound library. As a result, we identified potent, selective, and orally bioavailable ASK1 inhibitors for wide range of therapeutic targets.
FUSED HETEROCYCLIC COMPOUND
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Page/Page column 89-90, (2009/06/27)
The present invention provides a compound represented by the formula (I): wherein ring A is a ring which is optionally further substituted; R1 is a hydrogen atom or a substituent; R2 is a hydrogen atom or a substituent; R3
