1005785-45-4 Usage
General Description
6-Chloroimidazo[1,2-a]pyridin-2-amine is a synthetic compound that belongs to the class of organic compounds known as imidazo[1,2-a]pyridines. These are compounds containing an imidazo[1,2a]pyridine ring system, which is a tricyclic compound that consists of an imidazole ring fused to a pyridine ring. 6-Chloroimidazo[1,2-a]pyridin-2-amine is used primarily as a synthetic reagent in the production of various pharmaceutical and agrochemical products due to its unique structural properties. As with most chemicals, safety precautions are required when handling, as its potential effects on human health and the environment are yet to be comprehensively studied.
Check Digit Verification of cas no
The CAS Registry Mumber 1005785-45-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,5,7,8 and 5 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1005785-45:
(9*1)+(8*0)+(7*0)+(6*5)+(5*7)+(4*8)+(3*5)+(2*4)+(1*5)=134
134 % 10 = 4
So 1005785-45-4 is a valid CAS Registry Number.
1005785-45-4Relevant articles and documents
Design, synthesis and biological evaluation of imidazo[1,2-a]pyridine analogues or derivatives as anti-helmintic drug
Zhou, Shiyang,Chen, Guangying,Huang, Gangliang
, p. 503 - 510 (2019)
The Albendazole was used as the lead compound, which was modified by structural transformation and with alkyl groups. A total of 18 compounds (4a–4r) were designed and synthesized. The in vitro experiment results showed that compounds 4e, 4f, 4k, 4l, 4q and 4r had good inhibitory effect on egg and imago of roundworm. IC50 of compound 4l to anti-egg of roundworm was 0.65?±?0.01?μmol/L and to anti-imago of roundworm was 1.04?±?0.01?μmol/L. At the same time, it showed that compound 4l had the best effect in vivo, and the rate of anti-helmintic could reach more than 99%. The results of acute toxicity tests indicated that these compounds were with LD50 > 2100 mg/kg by oral administration, so they were low toxicity compounds. In a word, compound 4l was most likely to be a new anti-helmintic drug through screening in vitro and in vivo.
