100581-95-1Relevant academic research and scientific papers
Compound, application thereof, platinum coordination complex and liposome thereof
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Paragraph 0190-0194, (2017/08/31)
The invention relates to the field of medicines, in particular to a compound, application thereof, a platinum coordination complex and liposome thereof. The platinum coordination complex disclosed by the invention can be well combined with a membrane material of the liposome, so that encapsulation efficiency and drug loading capacity of the liposome are improved; furthermore, the platinum coordination complex disclosed by the invention contains carboxyl and has pH sensitivity; the carboxyl trends to be deprotonated in lower pH value environment (such as tumor tissues), so that release of medicine in the tumor tissues is improved, and a curing effect of medicine is improved. Experiments show that the liposome disclosed by the invention can reduce toxic and side effects of the medicine and improve medicine effects.
