1006-96-8

Usage

Uses

Used in Insect Repellent Products:
Picaridin is utilized as an active ingredient in various insect repellent formulations for its ability to provide reliable protection against a wide range of insects. It is particularly favored for its non-irritating and non-oily properties, making it suitable for sensitive skin and preferred by individuals engaging in outdoor activities.
Used in Outdoor Recreation:
In the outdoor recreation industry, picaridin is used as a key component in insect repellent products to ensure that participants can enjoy their activities without the discomfort and health risks associated with insect bites. Its effectiveness and safety profile make it an ideal choice for hikers, campers, and other outdoor enthusiasts.
Used in Public Health Initiatives:
Picaridin is employed in public health initiatives aimed at reducing the transmission of insect-borne diseases. Its approval by health organizations and endorsement as a reliable means of insect bite prevention make it a valuable tool in combating vector-borne illnesses such as malaria, Lyme disease, and Zika virus.
Used in Travel and Expedition Supplies:
For the travel and expedition industry, picaridin is incorporated into insect repellent products to provide essential protection for travelers visiting regions where insect-borne diseases are prevalent. Its effectiveness and user-friendly formulation make it a convenient and reliable option for those seeking to safeguard their health during their journeys.

Upstream product

• 1003-67-4 4-methylpyridine-1-oxide 
• 108-24-7 acetic anhydride 
• 108-89-4 picoline 

Downstream Products

• 1121-19-3 4-methylpyridin-3-ol 
• 15128-89-9 2-nitro-3-hydroxy-4-methylpyridine 
• 943994-61-4 ethyl [(6-bromo-4-methyl-2-nitropyridin-3-yl)oxy]acetate 

Relevant academic research and scientific papers

BENZOXAZINONE DERIVATIVES AND ANALOGUES THEREOF AS MODULATORS OF TNF ACTIVITY

A series of substituted 3,4-dihydro-2H-.1,4-benzoxazin-3-one derivatives, and analogues thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune

Structure activity relationship of pyridoxazinone substituted RHS analogs of oxabicyclooctane-linked 1,5-naphthyridinyl novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-6)

Abstract Oxabicyclooctane linked 1,5-naphthyridinyl-pyridoxazinones are novel broad-spectrum bacterial topoisomerase inhibitors (NBTIs) targeting bacterial DNA gyrase and topoisomerase IV at a site different than quinolones. Due to lack of cross-resistance to known antibiotics they present excellent opportunity to combat drug-resistant bacteria. A structure activity relationship of the pyridoxazinone moiety is described in this Letter. Chemical synthesis and activities of NBTIs with substitutions at C-3, C-4 and C-7 of the pyridoxazinone moiety with halogens, alkyl groups and methoxy group has been described. In addition, substitutions of the linker NH proton and its transformation into amide analogs of AM-8085 and AM-8191 have been reported. Fluoro, chloro, and methyl groups at C-3 of the pyridoxazinone moiety retained the potency and spectrum. In addition, a C-3 fluoro analog showed 4-fold better oral efficacy (ED50 3.9 mg/kg) as compared to the parent AM-8085 in a murine bacteremia model of infection of Staphylococcus aureus. Even modest polarity (e.g., methoxy) is not tolerated at C-3 of the pyridoxazinone unit. The basicity and NH group of the linker is important for the activity when CH2 is at the linker position-8. However, amides (with linker position-8 ketone) with a position-7 NH or N-methyl group retained potency and spectrum suggesting that neither basicity nor hydrogen-donor properties of the linker amide NH is essential for the activity. This would suggest likely an altered binding mode of the linker position-7,8 amide containing compounds. The amides showed highly improved hERG (functional IC50 >30 μM) profile.