1006032-31-0

Basic information

• Product Name: C₂₄H₃₂O₄SeSi
• Synonyms: C₂₄H₃₂O₄SeSi
• CAS NO: 1006032-31-0
• Molecular Weight: 491.561
• Mol File: 1006032-31-0.mol

Chemical Properties

• CAS DataBase Reference: C₂₄H₃₂O₄SeSi(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₃₂O₄SeSi(1006032-31-0)
• EPA Substance Registry System: C₂₄H₃₂O₄SeSi(1006032-31-0)

Safety Data

• Hazardous Substances Data: 1006032-31-0(Hazardous Substances Data)

Upstream product

• 89747-54-6 (3R,4R,5R)-4,5-dihydro-3,4-(O,O)-isopropylidene-5-mesyloxymethyl-2-(3H)-furanone 
• 30725-00-9 2,3-O-isopropylidene-D-ribonic-γ-lactone 
• 1320269-76-8 (3aR,6S,6aR)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4(3aH)-one 
• 152006-17-2 2,3-O-isopropylidene-L-lyxono-1,4-lactone 
• 1006032-29-6 5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-1,4-di-O-methanesulfonyl-L-lyxitol 
• 1006364-60-8 5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-L-lyxitol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 1006032-30-9 (3aS,4R,6aR)-tetrahydro-4-([(tert-butyl)dimethylsilyloxy]methyl)-2,2-dimethylselenopheno[3,4-d][1,3]dioxole 

Downstream Products

• 1006032-34-3 N⁴-benzoyl-1-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-4-seleno-β-D-ribofuranosyl)cytosine 
• 1006032-32-1 acetic acid 6-(tert-butyldiphenylsilanyloxymethyl)-2,2-dimethyltetrahydro-1,3-dioxa-5-selenapentalen-4-yl ester 
• 1006032-33-2 1-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-4-seleno-β-D-ribofuranosyl)uracil 
• 1006032-33-2 1-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-4-seleno-β-D-ribofuranosyl)uracil 
• 1030021-65-8 1-(5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-4-seleno-β-D-ribofuranosyl)thymine 
• 1433368-87-6 7-[6-(tert-butyl-diphenylsilanyloxymethyl)-2,2-dimethyltetrahydro-1,3-dioxa-5-selenapentalen-4-yl]-6-chloro-7H-purin-2-ylamine 
• 1433368-95-6 2-amino-6-chloro-9-(2,3-O-isopropylidene-5-O-tert-butyldiphenylsilyl-4-seleno-β-D-ribofuranosyl)-9H-purine 
• 1433368-79-6 7-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-1,3-dioxa-5-selena-pentalen-4-yl]-6-chloro-7H-purine 
• 1433368-71-8 9-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-1,3-dioxa-5-selena-pentalen-4-yl]-6-chloro-9H-purine 
• 1433369-48-2 2-amino-9-[6-((tert-butyl)diphenylsilanyloxymethyl)-2,2-dimethyltetrahydro-1,3-dioxa-5-selenapentalen-4-yl]-1,9-dihydropurin-6-one 
• 1620879-34-6 (+)-N³-benzoyl-5-chloro-1-[2-azido-2-deoxy-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-seleno-D-arabinofuranosyl]uracil 
• 1620879-35-7 (-)-N³-benzoyl-5-bromo-1-[2-azido-2-deoxy-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-seleno-D-arabinofuranosyl]uracil 
• 1620879-36-8 (-)-N³-benzoyl-5-iodo-1-[2-azido-2-deoxy-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-seleno-D-arabinofuranosyl]uracil 
• 1620879-37-9 (+)-N³-benzoyl-1-(2-azido-2-deoxy-4-seleno-D-arabinofuranosyl)uracil 

Relevant articles and documents

Structure-activity relationships of 2′-modified-4′- selenoarabinofuranosyl-pyrimidines as anticancer agents

Based on the potent anticancer activity of the D-arabino-configured cytosine nucleoside ara-C, novel 2′-substituted-4′- selenoarabinofuranosyl pyrimidines 3a-3u, comprising azido, fluoro, and hydroxyl substituents at C-2′ were designed, synthesized, and evaluated for anticancer activity. The 2′-azido group was stereoselectively introduced by the Mitsunobu reaction using diphenylphosphoryl azide (DPPA), and the 2′-fluoro group was stereoselectively introduced through the double inversions of stereochemistry via the episelenium intermediate, which was formed by the participation of the selenium atom. Among the compounds tested, the 2′-fluoro derivative 3t (X = NH2, Y = H, R = F) was found to be the most potent anticancer agent and showed more potent anticancer activity than the control, ara-C in all tested human cancer cell lines (HCT116, A549, SNU638, T47D, and PC-3) except the leukemia cell lines (K562). The anticancer activity of the 2′-substituted-4′-selenonucleosides is in the following order: 2′-F > 2′-OH > 2′-N3.

New RNA purine building blocks, 4'-selenopurine nucleosides: First synthesis and unusual mixture of sugar puckerings

Writer's blocks: The first synthesis of RNA purine building blocks, 4'-selenoadenosine and 4'-selenoguanosine was achieved from D-ribose by regioisomeric rearrangement, which was confirmed by X-ray crystallography. 4'-Selenoadenosine exists in an unusual mixture of north and south conformers in the solid state.

First synthesis of 4′-selenonucleosides showing unusual southern conformation

(Chemical Equation Presented) The first synthesis of 4′- selenonucleosides was achieved using a Pummerer-type condensation as a key step. All stereoelectronic effects shown in 4′-oxonucleosides were overwhelmed by the size of selenium and steric interacti

Stereoselective synthesis and conformational study of novel 2′,3′-didehydro-2′,3′-dideoxy-4′-selenonucleosides

(Chemical Equation Presented) Stereoselective synthesis of novel 2′,3′-didehydro-2′,3′-dideoxy-4′- selenonucleosides (4′-seleno-d4Ns) 4a-c was accomplished via 4′-selenoribofuranosyl pyrimidines 11a-c, as key intermediates. 4′-Selenoribofuranosyl pyrimidi