1006035-85-3Relevant academic research and scientific papers
Discovery of orally active, pyrrolidinone-based progesterone receptor partial agonists
Washburn, David G.,Hoang, Tram H.,Frazee, James S.,Johnson, Latisha,Hammond, Marlys,Manns, Sharada,Madauss, Kevin P.,Williams, Shawn P.,Duraiswami, Chaya,Tran, Thuy B.,Stewart, Eugene L.,Grygielko, Eugene T.,Glace, Lindsay E.,Trizna, Walter,Nagilla, Rakesh,Bray, Jeffrey D.,Thompson, Scott K.
experimental part, p. 4664 - 4668 (2010/04/28)
We have designed and synthesized a novel series of pyrrolidinones as progesterone receptor partial agonists. Compounds from this series had improved AR selectivity, rat pharmacokinetic properties, and in vivo potency compared to the lead compound. In addi
PYRROLIDINONE ANILINES AS PROGESTERONE RECEPTOR MODULATORS
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Page/Page column 8-9, (2008/06/13)
The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a combination thereof, wherein R1, R2, and X are as defined herein. Compounds o
