1006040-67-0Relevant academic research and scientific papers
Kinesin spindle protein (KSP) inhibitors. Part V: Discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by β-fluorination to overcome cellular efflux by P-glycoprotein
Cox, Christopher D.,Breslin, Michael J.,Whitman, David B.,Coleman, Paul J.,Garbaccio, Robert M.,Fraley, Mark E.,Zrada, Matthew M.,Buser, Carolyn A.,Walsh, Eileen S.,Hamilton, Kelly,Lobell, Robert B.,Tao, Weikang,Abrams, Marc T.,South, Vicki J.,Huber, Hans E.,Kohl, Nancy E.,Hartman, George D.
, p. 2697 - 2702 (2008/02/05)
Installation of a C2-aminopropyl side chain to the 2,4-diaryl-2,5-dihydropyrrole series of kinesin spindle protein (KSP) inhibitors results in potent, water soluble compounds, but the aminopropyl group induces susceptibility to cellular efflux by P-glycop
