100618-27-7

Upstream product

• 10544-63-5 ethyl crotonate 
• 106-49-0 p-toluidine 
• 158261-84-8 (Z)-3-(4-methyl-phenylamino)-but-2-enoic acid ethyl ester 
• 99-99-0 1-methyl-4-nitrobenzene 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 1014697-64-3 ethyl 3-[N-(2-iodo-4-methylphenyl)amino]butanoate 
• 101730-18-1 2,3-dihydro-2,6-dimethyl-1-[(4-methylphenyl)sulfonyl]-4(1H)-quinolinone 
• 859917-53-6 3-[N-(toluene-4-sulfonyl)-p-toluidino]-butyric acid 

Relevant academic research and scientific papers

A one-pot synthesis of N-alkylaminobenzenes from nitroaromatics: reduction followed by reductive amination using B10H14

N-Alkylaminobenzenes were prepared in a simple and efficient one-pot synthesis by reduction of nitrobenzenes followed by reductive amination with decaborane (B10H14) in the presence of 10% Pd/C.

Synthesis of indole-3-carboxylic acid derivatives by Pd(0)-catalyzed intramolecular α-arylation of β-(2-iodoanilino) esters

(Chemical Equation Presented) β-(2-Iodoanilino) esters undergo intramolecular α-arylation in the presence of Pd(PPh3) 4 and potassium phenoxide. The reaction is a useful methodology for the preparation of indole-3-carboxylic acid ester derivatives.

Chemo- and diastereoselective reduction of β-enamino esters: A convenient synthesis of both cis- and trans-γ-amino alcohols and β-amino esters

Convenient procedures for the chemo- and diastereoselective reduction of b-enamino esters 1 are described. Both cis- and trans-γ-amino alcohols 2 or b-amino esters 3 can be prepared by reduction of b-enamino esters 1, readily available starting materials, with the use of inexpensive reagents Na/i-PrOH or NaHB(OAc)3/AcOH, respectively, and the appropriate reduction conditions. The mechanisms and diastereoselectivities for the reductions are discussed. The relative configurations and conformations of the diastereoisomeric γ-amino alcohols 2 and β-amino esters 3 obtained are established by 1H and 13C NMR study and unequivocally set by their cyclic derivatives tetrahydro-1,3-oxazines 4.