100618-31-3Relevant academic research and scientific papers
Evaluation of ethyl: N -(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus
Stephens, Matthew D.,Yodsanit, Nisakorn,Melander, Christian
, p. 6853 - 6856 (2016/07/21)
A small molecule library consisting of 45 compounds was synthesized based on the bacterial metabolite ethyl N-(2-phenethyl) carbamate. Screening of the compounds revealed a potent analogue capabale of inhibiting several strains of Methicillin Resistant S. aureus biofilms with low to moderate micromolar IC50 values.
Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B
La Regina, Giuseppe,Silvestri, Romano,Gatti, Valerio,Lavecchia, Antonio,Novellino, Ettore,Befani, Olivia,Turini, Paola,Agostinelli, Enzo
experimental part, p. 9729 - 9740 (2009/04/06)
New monoamine oxidase inhibitors were synthesized as indole analogues of a previously reported pyrrole series. Several compounds were potent MAO-A (12, 17, 19-22, 31, 36, and 37) or MAO-B (14, 20, 24, 38, 44, and 46) inhibitors, and had Ki values in the nanomolar concentration range. In particular, 22 (Ki = 0.00092 μM, and SI = 68,478) was exceptionally potent and selective as MAO-A inhibitor. In molecular modeling studies, compounds 22, 24, 44, and 46 positioned the indole ring into an aromatic cavity of MAO-A, and established π-π stacking interactions with Tyr407, Tyr444, and FAD cofactor. However, only compound 22 was able to form hydrogen bonds with FAD, a finding which was in accordance with its potent anti-MAO-A activity. Conversely, 22/MAOB complex was highly unstable during the MD simulation.
Process for the preparation of N,o-substituted mono-and/or polyurethanes
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, (2008/06/13)
The invention describes a process for the preparation of N,o-substituted mono- and/or polyurethanes of formula in which R1 is an aliphatic, cycloaliphatic, aromatic, araliphatic, or heterocyclic radical, which may be substituted, R2 is an aliphatic, cycloaliphatic, or araliphatic radical which may be substituted with alkoxy or polyoxyalkylene groups, and is a whole number from 1 to 5, through the reaction of N-substituted allophanates and/or polyallophanates with alcohols R2 OH in the presence or absence of catalysts at temperatures of at least 160° C., preferably from 165° to 250° C.
Process for the production of N,O-disubstituted urethanes and use thereof as starting materials for the production of organic isocyanates
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, (2008/06/13)
The present invention is directed to a process for the production of N,O-disubstituted urethanes comprising reacting N-mono- or N,N'-disubstituted ureas or linear polyureas with aliphatic carbonic esters.
Process for the preparation of an aryl mono-, di-, and/or polyurethane
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, (2008/06/13)
A process for the preparation of an aryl-mono and/or polyurethane comprising the steps of A. reacting a primary aromatic mono, di-, and/or polyamine with an O-alkyl carbamate in the presence of alcohol and catalysts, and B. separating the ammonia and other by-products from the aliphatic and/or cycloaliphatic di- and/or polyurethane. The reaction is preferably carried out in the presence of urea. The aryl mono-, di-, and/or polyurethanes produced are valuable end and intermediate products. They can be transferred into the corresponding isocyanates which can then be used for the preparation of polyurethanes.
