100626-95-7Relevant academic research and scientific papers
Highly anti-anti selective synthesis of bis-β-amino ketones via three-component direct Mannich-type reaction of terephthalaldehyde catalyzed by ZrOCl2·8H2O
Eftekhari-Sis, Bagher,Saraei, Mahnaz,Bonyad-Bagheri, Mohammad
, p. 421 - 427 (2013)
At room temperature, zirconium oxychloride (ZrOCl2· 8H2O) efficiently catalyzes the direct Mannich-type reaction of a variety of in situ generated bis-imines using terephthalaldehyde and anilines with ketones in a three-component reaction at room temperature. The reaction proceeds rapidly and affords the corresponding bis-β-amino ketones in good-to-high yields with good-to-excellent anti-anti selectivity.
Exploration of imidazole and imidazopyridine dimers as anticancer agents: Design, synthesis, and structure–activity relationship study
Meenakshisundaram, Sangeetha,Manickam, Manoj,Pillaiyar, Thanigaimalai
, (2019/11/03)
Dimerization of proteins/receptors plays a critical role in various cellular processes, including cell proliferation and differentiation. Therefore, targeting such dimeric proteins/receptors by dimeric small molecules could be a potential therapeutic appr
