100632-83-5Relevant academic research and scientific papers
Antiarrhythmic N-aminoalkylene alkyl and aryl sulfonamides
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, (2008/06/13)
The present invention provides novel sulfonanilide and benzene-alkylaminium compounds which are the products of processes utilizing novel intermediates. Both the novel compounds and the novel intermediates are useful for the therapeutic or prophylactic treatment of arrhythmic activity.
N-[(ω-amino-1-hydroxyalkyl)phenyl]methanesulfonamide derivatives with Class III antiarrhythmic activity
Hester,Gibson,Cimini,Emmert,Locker,Perricone,Skaletzky,Sykes,West
, p. 308 - 315 (2007/10/02)
N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide, (E)-2-butenedioate (2:1) salt (ibutilide fumarate, 2E), has been found to have Class III antiarrhythmic activity. In an in vitro rabbit heart tissue preparation designed to evaluate the
